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    pck pickel [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31101, updated on 22-Aug-2024

    Summary

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    Official Symbol
    pckprovided by FlyBase
    Official Full Name
    pickelprovided by FlyBase
    Primary source
    FLYBASE:FBgn0013720
    Locus tag
    Dmel_CG14779
    See related
    AllianceGenome:FB:FBgn0013720
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14779; Dmel\CG14779; EG:80H7.2; l(1)G0044; mega; Mega; Pck; PCK
    Summary
    Involved in establishment of glial blood-brain barrier; open tracheal system development; and septate junction assembly. Located in septate junction. Is expressed in organism. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See pck in Genome Data Viewer
    Location:
    2A4-2A4; 1-0.2 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1470666..1472325)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1364699..1366358)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Rab27

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TEV protease-mediated cleavage in Drosophila as a tool to analyze protein functions in living organisms. Harder B, et al. Biotechniques, 2008 May. PMID 18476830
    2. The claudin Megatrachea protein complex. Jaspers MH, et al. J Biol Chem, 2012 Oct 26. PMID 22930751, Free PMC Article
    3. Conserved function of the matriptase-prostasin proteolytic cascade during epithelial morphogenesis. Drees L, et al. PLoS Genet, 2019 Jan. PMID 30601807, Free PMC Article
    4. Understanding functional miRNA-target interactions in vivo by site-specific genome engineering. Bassett AR, et al. Nat Commun, 2014 Aug 19. PMID 25135198, Free PMC Article
    5. The fatty acyl-CoA reductase Waterproof mediates airway clearance in Drosophila. Jaspers MH, et al. Dev Biol, 2014 Jan 1. PMID 24183938

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in establishment of glial blood-brain barrier IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in liquid clearance, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in open tracheal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of tube size, open tracheal system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of tube size, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in septate junction assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in septate junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in septate junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in septate junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in septate junction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pickel
    Names
    CG14779-PA
    CG14779-PC
    CG14779-PD
    megatrachea
    pck-PA
    pck-PC
    pck-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      1470666..1472325
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166887.3 → NP_726742.1  pickel, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726742.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E4NKM0, O76899
      Related
      FBpp0070245
      Conserved Domains (1) summary
      cl21598
      Location:39 → 211
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    2. NM_001038731.1 → NP_001033820.1  pickel, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001033820.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2PE37
      Conserved Domains (1) summary
      cl21598
      Location:39 → 92
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    3. NM_130563.4 → NP_569919.2  pickel, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_569919.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E4NKM0, O76899
      Related
      FBpp0070246
      Conserved Domains (1) summary
      cl21598
      Location:39 → 211
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O76899 O76899
    Q2PE37 Q2PE37
    Q8T098 Q8T098

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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