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    Rnf19a ring finger protein 19A [ Mus musculus (house mouse) ]

    Gene ID: 30945, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Rnf19aprovided by MGI
    Official Full Name
    ring finger protein 19Aprovided by MGI
    Primary source
    MGI:MGI:1353623
    See related
    Ensembl:ENSMUSG00000022280 AllianceGenome:MGI:1353623
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    XYbp; Rnf19; Dorfin; UIP117; Ubce7ip2
    Summary
    Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Involved in regulation of protein catabolic process at postsynapse, modulating synaptic transmission. Is active in glutamatergic synapse and hippocampal mossy fiber to CA3 synapse. Is expressed in several structures, including central nervous system; dorsal root ganglion; genitourinary system; retina; and tooth. Orthologous to human RNF19A (ring finger protein 19A, RBR E3 ubiquitin protein ligase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis adult (RPKM 56.1), liver E18 (RPKM 11.4) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rnf19a in Genome Data Viewer
    Location:
    15 B3.1; 15 14.46 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (36240080..36283293, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (36239934..36283147, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene sperm associated antigen 1 Neighboring gene predicted gene, 23754 Neighboring gene predicted gene, 41293 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:36144507-36144717 Neighboring gene microRNA 8097 Neighboring gene lactate dehydrogenase A pseudogene Neighboring gene ribosomal protein L7A, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. XYbp, a novel RING-finger protein, is a component of the XY body of spermatocytes and centrosomes. Párraga M, et al. Mech Dev, 2000 Jan. PMID 10585566
    2. Dorfin ameliorates phenotypes in a transgenic mouse model of amyotrophic lateral sclerosis. Sone J, et al. J Neurosci Res, 2010 Jan. PMID 19610091
    3. RNF19a inhibits antiviral immune response to RNA viruses through degradation of TBK1. Yang Y, et al. Mol Immunol, 2022 Mar. PMID 34990937
    4. Cloning and characterization of genes expressed during gametogenesis of female and male mice. López-Alañón DM, et al. J Reprod Fertil, 1995 Mar. PMID 7616504
    5. Mice lacking the PSD-95-interacting E3 ligase, Dorfin/Rnf19a, display reduced adult neurogenesis, enhanced long-term potentiation, and impaired contextual fear conditioning. Park H, et al. Sci Rep, 2015 Nov 10. PMID 26553645, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. H3K27me3 of Rnf19a promotes neuroinflammatory response during Japanese encephalitis virus infection.
      Title: H3K27me3 of Rnf19a promotes neuroinflammatory response during Japanese encephalitis virus infection.
    2. RNF19a inhibits antiviral immune response to RNA viruses through degradation of TBK1.
      Title: RNF19a inhibits antiviral immune response to RNA viruses through degradation of TBK1.
    3. These results suggest that Dorfin may regulate adult neurogenesis, synaptic plasticity, and contextual fear memory.
      Title: Mice lacking the PSD-95-interacting E3 ligase, Dorfin/Rnf19a, display reduced adult neurogenesis, enhanced long-term potentiation, and impaired contextual fear conditioning.
    4. In addition to causing a decrease in the amount of mutant SOD1 protein in the spinal cord, Dorfin overexpression ameliorated neurological phenotypes and motor neuron degeneration in a mouse model of amyotrophic lateral sclerosis.
      Title: Dorfin ameliorates phenotypes in a transgenic mouse model of amyotrophic lateral sclerosis.
    5. Dorfin ubiquitylated mutant SOD1 by recognizing the Cys(6)- and Cys(111)-disulfide cross-linked form and targeted it for proteasomal degradation
      Title: Disulfide bond mediates aggregation, toxicity, and ubiquitylation of familial amyotrophic lateral sclerosis-linked mutant SOD1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein catabolic process at postsynapse, modulating synaptic transmission EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in regulation of protein catabolic process at postsynapse, modulating synaptic transmission IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of protein catabolic process at postsynapse, modulating synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in hippocampal mossy fiber to CA3 synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in hippocampal mossy fiber to CA3 synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in hippocampal mossy fiber to CA3 synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF19A
    Names
    UBCM4-interacting protein 117
    XY body protein
    double ring-finger protein
    gametogenesis-expressed protein GEG-154
    ring finger protein (C3HC4 type) 19
    ubiquitin conjugating enzyme 7 interacting protein 2
    NP_001344560.1
    NP_038951.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357631.1 → NP_001344560.1  E3 ubiquitin-protein ligase RNF19A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC121577, AC147366
      Consensus CDS
      CCDS88749.1
      UniProtKB/TrEMBL
      A0A2I3BRK4
      Related
      ENSMUSP00000154617.2, ENSMUST00000228358.2
      Conserved Domains (4) summary
      smart00647
      Location:199 → 264
      IBR; In Between Ring fingers
      pfam01485
      Location:297 → 335
      IBR; IBR domain, a half RING-finger domain
      cd16775
      Location:131 → 185
      RING-HC_RBR_RNF19A; RING finger, HC subclass, found in RING finger protein 19A (RNF19A) and similar proteins
      cl00570
      Location:361 → 450
      AzlC; AzlC protein

    2. NM_013923.2 → NP_038951.1  E3 ubiquitin-protein ligase RNF19A isoform 1

      See identical proteins and their annotated locations for NP_038951.1

      Status: VALIDATED

      Source sequence(s)
      AK147768, BY207861, CN695058, CO432840, DV656092
      Consensus CDS
      CCDS27427.1
      UniProtKB/Swiss-Prot
      P50636, Q3UGT2, Q9QUJ5
      Related
      ENSMUSP00000022890.9, ENSMUST00000022890.10
      Conserved Domains (4) summary
      smart00184
      Location:132 → 179
      RING; Ring finger
      smart00647
      Location:199 → 264
      IBR; In Between Ring fingers
      pfam01485
      Location:297 → 335
      IBR; IBR domain, a half RING-finger domain
      cl00570
      Location:361 → 450
      AzlC; AzlC protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      36240080..36283293 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50636.2 GenPept UniProtKB/Swiss-Prot:P50636

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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