U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Ap3b2 adaptor related protein complex 3 subunit beta 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308777, updated on 15-Jun-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Ap3b2provided by RGD
    Official Full Name
    adaptor related protein complex 3 subunit beta 2provided by RGD
    Primary source
    RGD:1308950
    See related
    Ensembl:ENSRNOG00000019249 AllianceGenome:RGD:1308950
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in anterograde synaptic vesicle transport and vesicle-mediated transport. Predicted to be located in axon cytoplasm and clathrin-coated vesicle membrane. Predicted to be part of AP-3 adaptor complex. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 48. Orthologous to human AP3B2 (adaptor related protein complex 3 subunit beta 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 197.1), Uterus (RPKM 19.9) and 1 other tissue See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Ap3b2 in Genome Data Viewer
    Location:
    1q31
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (144821819..144854533, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (135412580..135445191, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (143284041..143315846, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene cytoplasmic polyadenylation element binding protein 1 Neighboring gene uncharacterized LOC134483747 Neighboring gene uncharacterized LOC134483748 Neighboring gene uncharacterized LOC102555928 Neighboring gene cDNA sequence BC048679-like Neighboring gene small Cajal body-specific RNA 15

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Phosphatidylinositol 4-kinase IIα function at endosomes is regulated by the ubiquitin ligase Itch. Mössinger J, et al. EMBO Rep, 2012 Dec. PMID 23146885, Free PMC Article
    2. The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse. Larimore J, et al. Mol Biol Cell, 2011 Dec. PMID 21998198, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in anterograde axonal transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in anterograde synaptic vesicle transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in anterograde synaptic vesicle transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic vesicle endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    AP-3 complex subunit beta-2
    Names
    adaptor-related protein complex 3, beta 2 subunit

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107532.2 → NP_001101002.2  AP-3 complex subunit beta-2

      Status: VALIDATED

      Source sequence(s)
      FQ085944, JAXUCZ010000001
      UniProtKB/TrEMBL
      A6JCF9
      Related
      ENSRNOT00000026030.8
      Conserved Domains (3) summary
      sd00044
      Location:111 → 139
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:34 → 590
      Adaptin_N; Adaptin N terminal region
      pfam14796
      Location:804 → 947
      AP3B1_C; Clathrin-adaptor complex-3 beta-1 subunit C-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      144821819..144854533 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262715.1 → XP_063118785.1  AP-3 complex subunit beta-2 isoform X3

      UniProtKB/TrEMBL
      A6JCF9

    2. XM_063262713.1 → XP_063118783.1  AP-3 complex subunit beta-2 isoform X2

      UniProtKB/TrEMBL
      A6JCF9

    3. XM_063262712.1 → XP_063118782.1  AP-3 complex subunit beta-2 isoform X1

      UniProtKB/TrEMBL
      A6JCF9
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.