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    Terb1 telomere repeat binding bouquet formation protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307615, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Terb1provided by RGD
    Official Full Name
    telomere repeat binding bouquet formation protein 1provided by RGD
    Primary source
    RGD:1310400
    See related
    EnsemblRapid:ENSRNOG00000055097 AllianceGenome:RGD:1310400
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ccdc79; RGD1310400
    Summary
    Predicted to be involved in meiotic telomere clustering. Predicted to act upstream of or within double-strand break repair involved in meiotic recombination; homologous chromosome pairing at meiosis; and meiotic attachment of telomere to nuclear envelope. Predicted to be located in chromosome, telomeric region and nuclear inner membrane. Predicted to be part of shelterin complex. Human ortholog(s) of this gene implicated in spermatogenic failure 60. Orthologous to human TERB1 (telomere repeat binding bouquet formation protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 50.1), Kidney (RPKM 10.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Terb1 in Genome Data Viewer
    Location:
    19p14
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (480160..534534)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (473720..528069)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (682013..736358)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene carbonic anhydrase 7 Neighboring gene NEDD8 activating enzyme E1 subunit 1 Neighboring gene U6 spliceosomal RNA Neighboring gene dynein, cytoplasmic 1 light intermediate chain 2 Neighboring gene CKLF-like MARVEL transmembrane domain containing 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mouse CCDC79 (TERB1) is a meiosis-specific telomere associated protein. Daniel K, et al. BMC Cell Biol, 2014 May 22. PMID 24885367, Free PMC Article
    2. MAJIN Links Telomeric DNA to the Nuclear Membrane by Exchanging Telomere Cap. Shibuya H, et al. Cell, 2015 Nov 19. PMID 26548954
    3. The TRF1-binding protein TERB1 promotes chromosome movement and telomere rigidity in meiosis. Shibuya H, et al. Nat Cell Biol, 2014 Feb. PMID 24413433
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within double-strand break repair involved in meiotic recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within homologous chromosome pairing at meiosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in homologous chromosome pairing at meiosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within meiotic attachment of telomere to nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in meiotic attachment of telomere to nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in meiotic telomere clustering ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of shelterin complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    telomere repeat binding bouquet formation protein 1; telomere repeats-binding bouquet formation protein 1
    Names
    coiled-coil domain containing 79

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431307.1 → NP_001418236.1  telomere repeat binding bouquet formation protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019

    2. NM_001431308.1 → NP_001418237.1  telomere repeat binding bouquet formation protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019

    3. NM_001431309.1 → NP_001418238.1  telomere repeat binding bouquet formation protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019

    4. NM_001431310.1 → NP_001418239.1  telomere repeat binding bouquet formation protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019

    5. NM_001431311.1 → NP_001418240.1  telomere repeat binding bouquet formation protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019

    6. NM_001431312.1 → NP_001418241.1  telomere repeat binding bouquet formation protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      480160..534534
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008772251.4 → XP_008770473.1  telomere repeats-binding bouquet formation protein 1 isoform X1

      Related
      ENSRNOP00000075491.2, ENSRNOT00000087469.3
      Conserved Domains (1) summary
      cd11658
      Location:715 → 760
      SANT_DMAP1_like; SANT/myb-like domain of Human Dna Methyltransferase 1 Associated Protein 1-like

    2. XM_063278878.1 → XP_063134948.1  telomere repeats-binding bouquet formation protein 1 isoform X3

      Related
      ENSRNOP00000110188.1, ENSRNOT00000150865.1

    3. XM_063278877.1 → XP_063134947.1  telomere repeats-binding bouquet formation protein 1 isoform X2

    4. XM_008772252.4 → XP_008770474.1  telomere repeats-binding bouquet formation protein 1 isoform X2

      Conserved Domains (3) summary
      smart00717
      Location:711 → 760
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11658
      Location:714 → 759
      SANT_DMAP1_like; SANT/myb-like domain of Human Dna Methyltransferase 1 Associated Protein 1-like
      cd00020
      Location:16 → 88
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

    5. XM_008772255.4 → XP_008770477.1  telomere repeats-binding bouquet formation protein 1 isoform X4

      See identical proteins and their annotated locations for XP_008770477.1

      UniProtKB/TrEMBL
      A0A0G2KAQ9
      Conserved Domains (3) summary
      smart00717
      Location:661 → 710
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11658
      Location:664 → 709
      SANT_DMAP1_like; SANT/myb-like domain of Human Dna Methyltransferase 1 Associated Protein 1-like
      cd00020
      Location:16 → 88
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

    6. XM_008772256.4 → XP_008770478.1  telomere repeats-binding bouquet formation protein 1 isoform X5

      See identical proteins and their annotated locations for XP_008770478.1

      UniProtKB/TrEMBL
      A0A0G2KAQ9
      Conserved Domains (3) summary
      smart00717
      Location:660 → 709
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11658
      Location:663 → 708
      SANT_DMAP1_like; SANT/myb-like domain of Human Dna Methyltransferase 1 Associated Protein 1-like
      cd00020
      Location:16 → 88
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

    7. XM_063278879.1 → XP_063134949.1  telomere repeats-binding bouquet formation protein 1 isoform X6

    8. XM_039098321.2 → XP_038954249.1  telomere repeats-binding bouquet formation protein 1 isoform X7

    Nucleotide Protein Strain
    Heading Accession and Version

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