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    Wdr19 WD repeat domain 19 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305349, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Wdr19provided by RGD
    Official Full Name
    WD repeat domain 19provided by RGD
    Primary source
    RGD:1306997
    See related
    EnsemblRapid:ENSRNOG00000002932 AllianceGenome:RGD:1306997
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306997
    Summary
    Predicted to be involved in cilium organization; protein localization to ciliary membrane; and protein-containing complex assembly. Predicted to act upstream of or within several processes, including chordate embryonic development; embryonic organ development; and myotome development. Predicted to be located in motile cilium and photoreceptor connecting cilium. Predicted to be part of intraciliary transport particle A. Predicted to be active in cilium. Human ortholog(s) of this gene implicated in several diseases, including Caroli disease; Senior-Loken syndrome; asphyxiating thoracic dystrophy 5; cranioectodermal dysplasia 4; and nephronophthisis 13. Orthologous to human WDR19 (WD repeat domain 19). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 80.0), Brain (RPKM 72.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Wdr19 in Genome Data Viewer
    Location:
    14p11
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (43396130..43460012, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (43042474..43106337, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (44705012..44767120, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S13 pseudogene Neighboring gene replication factor C subunit 1 Neighboring gene small nucleolar RNA SNORA77 Neighboring gene heterogeneous nuclear ribonucleoprotein A1, pseudogene 12 Neighboring gene solute carrier family 25, member 51 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Hepatorenal fibrocystic diseases in children. Park E, et al. Pediatr Nephrol, 2016 Jan. PMID 26260382
    2. Nephronophthisis 13: implications of its association with Caroli disease and altered intracellular localization of WDR19 in the kidney. Lee JM, et al. Pediatr Nephrol, 2015 Sep. PMID 25726036
    3. WDR19: an ancient, retrograde, intraflagellar ciliary protein is mutated in autosomal recessive retinitis pigmentosa and in Senior-Loken syndrome. Coussa RG, et al. Clin Genet, 2013 Aug. PMID 23683095, Free PMC Article
    4. Ciliopathies with skeletal anomalies and renal insufficiency due to mutations in the IFT-A gene WDR19. Bredrup C, et al. Am J Hum Genet, 2011 Nov 11. PMID 22019273, Free PMC Article
    5. Essential role of nephrocystin in photoreceptor intraflagellar transport in mouse. Jiang ST, et al. Hum Mol Genet, 2009 May 1. PMID 19208653

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within digestive system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ear morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic camera-type eye development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic cranial skeleton morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic limb morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within gonad development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intraciliary retrograde transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within intraciliary retrograde transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within myotome development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within nervous system process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to ciliary membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within receptor clustering ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within smoothened signaling pathway involved in dorsal/ventral neural tube patterning ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of intraciliary transport particle A IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of intraciliary transport particle A ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in non-motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in photoreceptor connecting cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat-containing protein 19

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191679.2 → NP_001178608.2  WD repeat-containing protein 19

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I6GJJ5, F1LV01
      Related
      ENSRNOP00000003991.5, ENSRNOT00000003991.8
      Conserved Domains (10) summary
      smart00299
      Location:851 → 964
      CLH; Clathrin heavy chain repeat homology
      COG0457
      Location:755 → 1045
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      COG2319
      Location:19 → 345
      WD40; WD40 repeat [General function prediction only]
      sd00006
      Location:779 → 803
      TPR; TPR repeat [structural motif]
      cd15832
      Location:903 → 947
      SNAP; TPR repeat [structural motif]
      pfam12773
      Location:1253 → 1296
      DZR; Double zinc ribbon
      pfam15911
      Location:508 → 564
      WD40_3; WD domain, G-beta repeat
      sd00039
      Location:20 → 55
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:25 → 157
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl24038
      Location:902 → 1065
      SNAP; Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      43396130..43460012 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039091922.2 → XP_038947850.1  WD repeat-containing protein 19 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GJJ5
      Conserved Domains (6) summary
      COG2319
      Location:19 → 345
      WD40; WD40 repeat [General function prediction only]
      cd15832
      Location:911 → 955
      SNAP; TPR repeat [structural motif]
      sd00039
      Location:20 → 55
      7WD40; WD40 repeat [structural motif]
      pfam15911
      Location:508 → 564
      WD40_3; WD domain, G-beta repeat
      cl24038
      Location:910 → 1073
      SNAP; Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family
      cl26078
      Location:919 → 972
      Clathrin; Region in Clathrin and VPS
    Nucleotide Protein Strain
    Heading Accession and Version

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