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    Rabgap1l RAB GTPase activating protein 1-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304914, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Rabgap1lprovided by RGD
    Official Full Name
    RAB GTPase activating protein 1-likeprovided by RGD
    Primary source
    RGD:1304620
    See related
    EnsemblRapid:ENSRNOG00000002736 AllianceGenome:RGD:1304620
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1304620
    Summary
    Predicted to enable GTPase activator activity and small GTPase binding activity. Predicted to be involved in regulation of protein localization. Predicted to be located in several cellular components, including Golgi apparatus; cilium; and early endosome. Orthologous to human RABGAP1L (RAB GTPase activating protein 1 like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 85.3), Spleen (RPKM 76.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rabgap1l in Genome Data Viewer
    Location:
    13q22
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (74997542..75593240, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (72464114..73059845, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (77975392..78609009, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481579 Neighboring gene calcyclin binding protein Neighboring gene small nucleolar RNA SNORA67 Neighboring gene PHD finger-like domain-containing protein 5A Neighboring gene G protein-coupled receptor 52 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene ribosomal protein L7-like 1, pseudogene 1 Neighboring gene large ribosomal subunit protein eL21-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity. Itoh T, et al. Genes Cells, 2006 Sep. PMID 16923123
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    NOT involved_in regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rab GTPase-activating protein 1-like

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107190.1 → NP_001100660.1  rab GTPase-activating protein 1-like isoform 2

      See identical proteins and their annotated locations for NP_001100660.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473958
      UniProtKB/TrEMBL
      A6ID63, D3ZKH6
      Related
      ENSRNOP00000075539.3, ENSRNOT00000087506.3
      Conserved Domains (3) summary
      cd01211
      Location:129 → 257
      PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
      pfam00566
      Location:541 → 744
      RabGAP-TBC; Rab-GTPase-TBC domain
      pfam12473
      Location:340 → 421
      DUF3694; Kinesin protein

    2. NM_001401442.2 → NP_001388371.1  rab GTPase-activating protein 1-like isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A8I6G9C0
      Related
      ENSRNOP00000093938.2, ENSRNOT00000076272.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      74997542..75593240 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006250105.5 → XP_006250167.1  rab GTPase-activating protein 1-like isoform X3

      See identical proteins and their annotated locations for XP_006250167.1

      UniProtKB/TrEMBL
      A0A8I6G9C0
      Conserved Domains (3) summary
      cd01211
      Location:129 → 257
      PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
      pfam00566
      Location:541 → 744
      RabGAP-TBC; Rab-GTPase-TBC domain
      pfam12473
      Location:340 → 421
      DUF3694; Kinesin protein

    2. XM_006250106.5 → XP_006250168.1  rab GTPase-activating protein 1-like isoform X3

      See identical proteins and their annotated locations for XP_006250168.1

      UniProtKB/TrEMBL
      A0A8I6G9C0
      Conserved Domains (3) summary
      cd01211
      Location:129 → 257
      PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
      pfam00566
      Location:541 → 744
      RabGAP-TBC; Rab-GTPase-TBC domain
      pfam12473
      Location:340 → 421
      DUF3694; Kinesin protein

    3. XM_063272349.1 → XP_063128419.1  rab GTPase-activating protein 1-like isoform X1

    4. XM_063272350.1 → XP_063128420.1  rab GTPase-activating protein 1-like isoform X2

    5. XM_039090774.1 → XP_038946702.1  rab GTPase-activating protein 1-like isoform X8

      Conserved Domains (3) summary
      COG1196
      Location:461 → 666
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam00566
      Location:188 → 391
      RabGAP-TBC; Rab-GTPase-TBC domain
      pfam12473
      Location:3 → 68
      DUF3694; Kinesin protein

    6. XM_039090773.2 → XP_038946701.1  rab GTPase-activating protein 1-like isoform X7

      Conserved Domains (3) summary
      COG1196
      Location:482 → 687
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam00566
      Location:209 → 412
      RabGAP-TBC; Rab-GTPase-TBC domain
      pfam12473
      Location:7 → 89
      DUF3694; Kinesin protein

    7. XM_006250108.4 → XP_006250170.1  rab GTPase-activating protein 1-like isoform X9

      UniProtKB/TrEMBL
      A0A8I6GAC9
      Related
      ENSRNOP00000083125.1, ENSRNOT00000076902.3
      Conserved Domains (1) summary
      TIGR01843
      Location:155 → 323
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family

    8. XM_039090778.2 → XP_038946706.1  rab GTPase-activating protein 1-like isoform X11

    9. XM_008769644.4 → XP_008767866.1  rab GTPase-activating protein 1-like isoform X10

      See identical proteins and their annotated locations for XP_008767866.1

      UniProtKB/TrEMBL
      A0A8I6ARQ0
      Conserved Domains (1) summary
      COG1196
      Location:68 → 276
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    10. XM_039090777.2 → XP_038946705.1  rab GTPase-activating protein 1-like isoform X10

      UniProtKB/TrEMBL
      A0A8I6ARQ0
      Conserved Domains (1) summary
      COG1196
      Location:68 → 276
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    11. XM_008769643.4 → XP_008767865.1  rab GTPase-activating protein 1-like isoform X10

      See identical proteins and their annotated locations for XP_008767865.1

      UniProtKB/TrEMBL
      A0A8I6ARQ0
      Conserved Domains (1) summary
      COG1196
      Location:68 → 276
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    12. XM_017598819.3 → XP_017454308.1  rab GTPase-activating protein 1-like isoform X10

      UniProtKB/TrEMBL
      A0A8I6ARQ0
      Related
      ENSRNOP00000109416.1, ENSRNOT00000126092.1
      Conserved Domains (1) summary
      COG1196
      Location:68 → 276
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    13. XM_008769645.4 → XP_008767867.1  rab GTPase-activating protein 1-like isoform X12

      See identical proteins and their annotated locations for XP_008767867.1

      UniProtKB/TrEMBL
      A0A8I5ZNN4
      Related
      ENSRNOP00000108648.1, ENSRNOT00000114691.2
      Conserved Domains (1) summary
      TIGR01843
      Location:38 → 206
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family

    14. XM_006250107.5 → XP_006250169.1  rab GTPase-activating protein 1-like isoform X4

      See identical proteins and their annotated locations for XP_006250169.1

      UniProtKB/TrEMBL
      A6ID63, D3ZKH6
      Conserved Domains (3) summary
      cd01211
      Location:129 → 257
      PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
      pfam00566
      Location:541 → 744
      RabGAP-TBC; Rab-GTPase-TBC domain
      pfam12473
      Location:340 → 421
      DUF3694; Kinesin protein

    15. XM_063272353.1 → XP_063128423.1  rab GTPase-activating protein 1-like isoform X13

    16. XM_063272355.1 → XP_063128425.1  rab GTPase-activating protein 1-like isoform X14

    17. XM_063272354.1 → XP_063128424.1  rab GTPase-activating protein 1-like isoform X14

    18. XM_063272352.1 → XP_063128422.1  rab GTPase-activating protein 1-like isoform X6

      Related
      ENSRNOP00000084608.2, ENSRNOT00000076999.4

    19. XM_063272351.1 → XP_063128421.1  rab GTPase-activating protein 1-like isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version

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