prim1 DNA primase subunit 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: prim1provided by ZNC
Official Full Name: DNA primase subunit 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-990603-6
See related: Ensembl:ENSDARG00000040163 AllianceGenome:ZFIN:ZDB-GENE-990603-6
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fa12c04; wu:fa12c04
Summary: Predicted to enable DNA primase activity. Predicted to be involved in DNA replication, synthesis of RNA primer. Predicted to act upstream of or within DNA replication. Predicted to be part of alpha DNA polymerase:primase complex. Is expressed in several structures, including blastodisc; head; hematopoietic system; nervous system; and pectoral fin musculature. Orthologous to human PRIM1 (DNA primase subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 23

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (17839187..17848907)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (17912844..17922564)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mutation of prim1 causes extensive apoptosis of retinal neurons through the activation of DNA damage checkpoint and tumor suppressor protein p53.
Title: Mutation of DNA primase causes extensive apoptosis of retinal neurons through the activation of DNA damage checkpoint and tumor suppressor p53.

Submit: New GeneRIF Correction

General gene information

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Markers

PRIM1 (e-PCR)
- UniSTS:205437

fa12c04.s1 (e-PCR)
- UniSTS:188809

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA primase activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA primase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA replication	IEA Inferred from Electronic Annotation more info
involved_in DNA replication, synthesis of primer	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within DNA replication, synthesis of primer	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of DNA-directed RNA polymerase complex	IEA Inferred from Electronic Annotation more info
part_of alpha DNA polymerase:primase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of primosome complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNA primase small subunit

Names: primase polypeptide 1; primase, DNA, polypeptide 1

NP_958856.1

EC 2.7.7.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201448.1 → NP_958856.1 DNA primase small subunit

See identical proteins and their annotated locations for NP_958856.1

Status: PROVISIONAL

Source sequence(s)

BC047856

UniProtKB/TrEMBL

Q7ZUR8

Related

ENSDARP00000095418.4, ENSDART00000104647.6

Conserved Domains (1) summary

cd04860
Location:24 → 344

AE_Prim_S; AE_Prim_S: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. Primases are DNA-dependent RNA polymerases which synthesis the short RNA primers required for DNA replication. In addition to its ...