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    Fbxw12 F-box and WD repeat domain containing 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301015, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Fbxw12provided by RGD
    Official Full Name
    F-box and WD repeat domain containing 12provided by RGD
    Primary source
    RGD:1307859
    See related
    EnsemblRapid:ENSRNOG00000020720 AllianceGenome:RGD:1307859
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307859
    Summary
    Predicted to be active in cytoplasm. Orthologous to human FBXW12 (F-box and WD repeat domain containing 12). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Uterus (RPKM 1.3) and Testes (RPKM 0.3) See more
    Orthologs
    human all
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    Genomic context

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    See Fbxw12 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (118660777..118680565, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (109782315..109802086, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (117871409..117890944, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 51 Neighboring gene translation machinery associated 7 homolog Neighboring gene plexin B1 Neighboring gene cytochrome c oxidase subunit 6C, pseudogene 2 Neighboring gene serine peptidase inhibitor, Kazal type 8 Neighboring gene NME/NM23 nucleoside diphosphate kinase 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. Ebstein F, et al. Int J Biochem Cell Biol, 2009 May. PMID 19028597
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    F-box/WD repeat-containing protein 12
    Names
    F-box and WD-40 domain protein 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      118660777..118680565 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039082627.2 → XP_038938555.1  F-box/WD repeat-containing protein 12 isoform X2

      UniProtKB/TrEMBL
      A6I3B7
      Related
      ENSRNOP00000028113.8, ENSRNOT00000028113.8
      Conserved Domains (3) summary
      COG2319
      Location:121 → 317
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:155 → 192
      7WD40; WD40 repeat [structural motif]
      pfam12937
      Location:4 → 46
      F-box-like

    2. XM_063266473.1 → XP_063122543.1  F-box/WD repeat-containing protein 12 isoform X3

    3. XM_063266472.1 → XP_063122542.1  F-box/WD repeat-containing protein 12 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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