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    Bcl9l BCL9 like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300673, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Bcl9lprovided by RGD
    Official Full Name
    BCL9 likeprovided by RGD
    Primary source
    RGD:1309096
    See related
    EnsemblRapid:ENSRNOG00000012420 AllianceGenome:RGD:1309096
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable beta-catenin binding activity. Predicted to be involved in several processes, including canonical Wnt signaling pathway; negative regulation of transforming growth factor beta receptor signaling pathway; and positive regulation of epithelial to mesenchymal transition. Predicted to act upstream of or within skeletal muscle cell differentiation and somatic stem cell population maintenance. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of beta-catenin-TCF complex. Orthologous to human BCL9L (BCL9 like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 44.7), Adrenal (RPKM 44.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Bcl9l in Genome Data Viewer
    Location:
    8q22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (53708770..53738880)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (44811977..44840611)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (48805684..48835794)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene forkhead box R1 Neighboring gene uroplakin 2 Neighboring gene C-X-C motif chemokine receptor 5 Neighboring gene uncharacterized LOC120094133 Neighboring gene DEAD-box helicase 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Bcl9/Bcl9l are critical for Wnt-mediated regulation of stem cell traits in colon epithelium and adenocarcinomas. Deka J, et al. Cancer Res, 2010 Aug 15. PMID 20682801
    2. BCL9 is an essential component of canonical Wnt signaling that mediates the differentiation of myogenic progenitors during muscle regeneration. Brack AS, et al. Dev Biol, 2009 Nov 1. PMID 19699733, Free PMC Article
    3. A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential. Fritzmann J, et al. Gastroenterology, 2009 Jul. PMID 19328798
    4. Role of a BCL9-related beta-catenin-binding protein, B9L, in tumorigenesis induced by aberrant activation of Wnt signaling. Adachi S, et al. Cancer Res, 2004 Dec 1. PMID 15574752
    5. Constitutive scaffolding of multiple Wnt enhanceosome components by Legless/BCL9. van Tienen LM, et al. Elife, 2017 Mar 15. PMID 28296634, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables beta-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within myoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within skeletal muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within somatic stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of beta-catenin-TCF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of beta-catenin-TCF complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    B-cell CLL/lymphoma 9-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106817.1 → NP_001100287.1  B-cell CLL/lymphoma 9-like protein

      See identical proteins and their annotated locations for NP_001100287.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473975
      UniProtKB/TrEMBL
      A0A8I6GJW6, A6J400, D4A0D9
      Related
      ENSRNOP00000061788.1, ENSRNOT00000064041.3
      Conserved Domains (1) summary
      pfam11502
      Location:395 → 434
      BCL9; B-cell lymphoma 9 protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      53708770..53738880
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017595551.3 → XP_017451040.1  B-cell CLL/lymphoma 9-like protein isoform X2

      UniProtKB/TrEMBL
      A0A8I6A6Y0, A0A8I6AJN4
      Related
      ENSRNOP00000093456.1, ENSRNOT00000102843.2

    2. XM_039081056.2 → XP_038936984.1  B-cell CLL/lymphoma 9-like protein isoform X3

      UniProtKB/TrEMBL
      A0A8I6GJW6
      Conserved Domains (2) summary
      PHA03247
      Location:851 → 1314
      PHA03247; large tegument protein UL36; Provisional
      pfam11502
      Location:358 → 397
      BCL9; B-cell lymphoma 9 protein

    3. XM_017595552.3 → XP_017451041.1  B-cell CLL/lymphoma 9-like protein isoform X2

      UniProtKB/TrEMBL
      A0A8I6A6Y0, A0A8I6AJN4

    4. XM_006242923.5 → XP_006242985.1  B-cell CLL/lymphoma 9-like protein isoform X1

      UniProtKB/TrEMBL
      A0A8I6A6Y0
      Related
      ENSRNOP00000091789.2, ENSRNOT00000104981.2
      Conserved Domains (1) summary
      pfam11502
      Location:442 → 481
      BCL9; B-cell lymphoma 9 protein
    Nucleotide Protein Strain
    Heading Accession and Version

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