Tnnc2 troponin C2, fast skeletal type [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tnnc2provided by RGD
Official Full Name: troponin C2, fast skeletal typeprovided by RGD
Primary source: RGD:1311973
See related: EnsemblRapid:ENSRNOG00000015155 AllianceGenome:RGD:1311973
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable calcium ion binding activity. Predicted to contribute to actin binding activity. Predicted to be involved in regulation of muscle contraction and skeletal muscle contraction. Predicted to be part of troponin complex. Human ortholog(s) of this gene implicated in congenital myopathy 15. Orthologous to human TNNC2 (troponin C2, fast skeletal type). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 58522.7) See more
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (173932611..173935339, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (153513272..153516033, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (161243607..161246335, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tncs (e-PCR), detects polymorphism
- UniSTS:238172

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
contributes_to actin binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in skeletal muscle contraction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of troponin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of troponin complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: troponin C, skeletal muscle

Names: skeletal troponin C; troponin C type 2 (fast)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.