Wfdc5 WAP four-disulfide core domain 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Wfdc5provided by RGD
Official Full Name: WAP four-disulfide core domain 5provided by RGD
Primary source: RGD:1304986
See related: EnsemblRapid:ENSRNOG00000013760 AllianceGenome:RGD:1304986
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in antibacterial humoral response and innate immune response. Predicted to be active in extracellular space. Orthologous to human WFDC5 (WAP four-disulfide core domain 5). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in Lung (RPKM 3.7), Testes (RPKM 0.7) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 3q42

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (173268410..173274253, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (152849025..152854868, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (160567805..160573978, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in antibacterial humoral response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: WAP four-disulfide core domain protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106538.1 → NP_001100008.1 WAP four-disulfide core domain protein 5 precursor

See identical proteins and their annotated locations for NP_001100008.1

Status: PROVISIONAL

Source sequence(s)

CH474005

UniProtKB/TrEMBL

A6JX62, D3ZYQ4

Related

ENSRNOP00000018386.4, ENSRNOT00000018386.6

Conserved Domains (2) summary

pfam00095
Location:32 → 72

WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

cl00156
Location:62 → 120

WAP; whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of ...