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    Slf1 SMC5-SMC6 complex localization factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294601, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Slf1provided by RGD
    Official Full Name
    SMC5-SMC6 complex localization factor 1provided by RGD
    Primary source
    RGD:1304857
    See related
    EnsemblRapid:ENSRNOG00000040279 AllianceGenome:RGD:1304857
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ankrd32
    Summary
    Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including positive regulation of cellular component organization; positive regulation of double-strand break repair; and protein localization to site of double-strand break. Predicted to be located in centrosome; cytoplasm; and nucleus. Predicted to be part of nucleosome. Predicted to be active in nucleus and site of double-strand break. Orthologous to human SLF1 (SMC5-SMC6 complex localization factor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 87.1), Spleen (RPKM 83.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slf1 in Genome Data Viewer
    Location:
    2q11
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (8498776..8606251, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (6767015..6874428, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (4095126..4195819, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene multiple C2 and transmembrane domain containing 1 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1, pseudogene 9 Neighboring gene ribosomal protein L24, pseudogene 11 Neighboring gene uncharacterized LOC134485566 Neighboring gene KIAA0825 homolog Neighboring gene ribosomal protein L17, pseudogene 12 Neighboring gene ribosomal protein L35, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RAD18-BRCTx interaction is required for efficient repair of UV-induced DNA damage. Liu T, et al. DNA Repair (Amst), 2012 Feb 1. PMID 22036607, Free PMC Article
    2. BRCTx is a novel, highly conserved RAD18-interacting protein. Adams DJ, et al. Mol Cell Biol, 2005 Jan. PMID 15632077, Free PMC Article
    3. DNA repair. Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links. Räschle M, et al. Science, 2015 May 1. PMID 25931565, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of maintenance of mitotic sister chromatid cohesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to site of double-strand break IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear inclusion body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nucleosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in site of double-strand break IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SMC5-SMC6 complex localization factor protein 1
    Names
    ankyrin repeat domain 32
    ankyrin repeat domain-containing protein 32

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106400.1 → NP_001099870.1  SMC5-SMC6 complex localization factor protein 1

      See identical proteins and their annotated locations for NP_001099870.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473955
      UniProtKB/TrEMBL
      A6I4G9
      Related
      ENSRNOP00000110893.1, ENSRNOT00000125299.1
      Conserved Domains (4) summary
      cd00027
      Location:15 → 78
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      cd00204
      Location:804 → 925
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:812 → 899
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:808 → 839
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      8498776..8606251 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281458.1 → XP_063137528.1  SMC5-SMC6 complex localization factor protein 1 isoform X1

    2. XM_063281459.1 → XP_063137529.1  SMC5-SMC6 complex localization factor protein 1 isoform X2

    RNA

    1. XR_010063587.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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