Nlrp10 NLR family, pyrin domain containing 10 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nlrp10provided by RGD
Official Full Name: NLR family, pyrin domain containing 10provided by RGD
Primary source: RGD:1307387
See related: EnsemblRapid:ENSRNOG00000015082 AllianceGenome:RGD:1307387
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nalp10
Summary: Predicted to enable ATP hydrolysis activity and GTPase activity. Predicted to be involved in several processes, including positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; positive regulation of cytokine production; and positive regulation of defense response. Predicted to be located in cytoplasmic side of plasma membrane; cytosol; and nucleus. Predicted to be part of canonical inflammasome complex. Predicted to be active in cytoplasm. Orthologous to human NLRP10 (NLR family pyrin domain containing 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 18.9), Lung (RPKM 7.6) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q33

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (172357648..172365205, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (162922806..162930363, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (173521412..173528969, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NLRP10 is bound to ASC protein under resting conditions. It decreases with Abeta treatment, both in vitro and in vivo. Abeta-induced cathepsin released into the cytosol degrades NLRP10, allowing dissociation of NLRP3 and formation of the inflammasome.
Title: Glial uptake of amyloid beta induces NLRP3 inflammasome formation via cathepsin-dependent degradation of NLRP10.

Submit: New GeneRIF Correction

General gene information

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Markers

Nlrp10 (e-PCR), detects polymorphism
- UniSTS:502668

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in defense response to fungus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T-helper 1 type immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T-helper 17 type immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 alpha production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of canonical inflammasome complex	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: NACHT, LRR and PYD domains-containing protein 10

Names: NACHT, leucine rich repeat and PYD containing 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106291.1 → NP_001099761.1 NACHT, LRR and PYD domains-containing protein 10

See identical proteins and their annotated locations for NP_001099761.1

Status: PROVISIONAL

Source sequence(s)

CH473956

UniProtKB/TrEMBL

A6I7U9, D3ZUA2

Related

ENSRNOP00000020393.3, ENSRNOT00000020393.6

Conserved Domains (3) summary

smart00382
Location:161 → 298

AAA; ATPases associated with a variety of cellular activities

cd08321
Location:10 → 88

Pyrin_ASC-like; Pyrin Death Domain found in ASC

pfam05729
Location:165 → 316

NACHT; NACHT domain