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    Cep76 centrosomal protein 76 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291540, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cep76provided by RGD
    Official Full Name
    centrosomal protein 76provided by RGD
    Primary source
    RGD:1305183
    See related
    EnsemblRapid:ENSRNOG00000021918 AllianceGenome:RGD:1305183
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CSG11; RGD1305183
    Summary
    Predicted to be involved in regulation of centriole replication. Predicted to be located in centrosome. Predicted to be part of protein-containing complex. Predicted to be active in centriole. Orthologous to human CEP76 (centrosomal protein 76). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 57.8), Spleen (RPKM 52.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cep76 in Genome Data Viewer
    Location:
    18q12.1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (63444389..63478358, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (61174514..61208512, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (63364990..63394766, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene PRELI domain containing 3A Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene U1 spliceosomal RNA Neighboring gene spire-type actin nucleation factor 1 Neighboring gene proteasome assembly chaperone 2 Neighboring gene protein tyrosine phosphatase, non-receptor type 2 Neighboring gene uncharacterized LOC134482957

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cep76, a centrosomal protein that specifically restrains centriole reduplication. Tsang WY, et al. Dev Cell, 2009 May. PMID 19460342, Free PMC Article
    2. The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly. Kobayashi T, et al. J Cell Biol, 2014 Jan 20. PMID 24421332, Free PMC Article
    3. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in regulation of centriole replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of centriole replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein of 76 kDa
    Names
    centrosomal protein 76kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100514.1 → NP_001093984.1  centrosomal protein of 76 kDa

      See identical proteins and their annotated locations for NP_001093984.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A0G2K779, A6IXV7, G3V931
      Related
      ENSRNOP00000034590.5, ENSRNOT00000029431.7
      Conserved Domains (2) summary
      pfam15627
      Location:99 → 258
      CEP76-C2; CEP76 C2 domain
      cl17362
      Location:374 → 411
      Transglut_core; Transglutaminase-like superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      63444389..63478358 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096664.2 → XP_038952592.1  centrosomal protein of 76 kDa isoform X1

      UniProtKB/TrEMBL
      A0A0G2K779
      Related
      ENSRNOP00000074096.3, ENSRNOT00000090078.3
      Conserved Domains (2) summary
      pfam15627
      Location:99 → 258
      CEP76-C2; CEP76 C2 domain
      cl17362
      Location:374 → 411
      Transglut_core; Transglutaminase-like superfamily

    2. XM_063277193.1 → XP_063133263.1  centrosomal protein of 76 kDa isoform X3

    3. XM_063277194.1 → XP_063133264.1  centrosomal protein of 76 kDa isoform X5

    4. XM_039096665.2 → XP_038952593.1  centrosomal protein of 76 kDa isoform X6

      UniProtKB/TrEMBL
      A0A0G2K779
      Conserved Domains (2) summary
      pfam15627
      Location:96 → 183
      CEP76-C2; CEP76 C2 domain
      cl17362
      Location:299 → 336
      Transglut_core; Transglutaminase-like superfamily

    5. XM_039096666.2 → XP_038952594.1  centrosomal protein of 76 kDa isoform X7

      UniProtKB/TrEMBL
      A0A0G2K779
      Conserved Domains (2) summary
      pfam15627
      Location:75 → 162
      CEP76-C2; CEP76 C2 domain
      cl17362
      Location:278 → 315
      Transglut_core; Transglutaminase-like superfamily

    6. XM_006254858.5 → XP_006254920.1  centrosomal protein of 76 kDa isoform X2

      UniProtKB/TrEMBL
      A0A0G2K779
      Conserved Domains (2) summary
      pfam01841
      Location:344 → 390
      Transglut_core; Transglutaminase-like superfamily
      pfam15627
      Location:80 → 237
      CEP76-C2; CEP76 C2 domain

    7. XM_008772118.4 → XP_008770340.1  centrosomal protein of 76 kDa isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZP63, A0A8I6A403
      Related
      ENSRNOP00000079750.1, ENSRNOT00000095835.2
      Conserved Domains (2) summary
      pfam01841
      Location:303 → 349
      Transglut_core; Transglutaminase-like superfamily
      pfam15627
      Location:39 → 196
      CEP76-C2; CEP76 C2 domain

    8. XM_039096667.2 → XP_038952595.1  centrosomal protein of 76 kDa isoform X8

      Conserved Domains (1) summary
      cl17362
      Location:159 → 196
      Transglut_core; Transglutaminase-like superfamily

    RNA

    1. XR_005496004.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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