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    Lrrc46 leucine rich repeat containing 46 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287653, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Lrrc46provided by RGD
    Official Full Name
    leucine rich repeat containing 46provided by RGD
    Primary source
    RGD:1303311
    See related
    EnsemblRapid:ENSRNOG00000009902 AllianceGenome:RGD:1303311
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Orthologous to human LRRC46 (leucine rich repeat containing 46). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 1785.8) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lrrc46 in Genome Data Viewer
    Location:
    10q31
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (82517767..82530011, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (82021314..82033575, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (84971674..84983867, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene Sp6 transcription factor Neighboring gene secernin 2 Neighboring gene mitochondrial ribosomal protein L10 Neighboring gene oxysterol binding protein-like 7 Neighboring gene T-box transcription factor 21

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. Hasson SA, et al. Nature, 2013 Dec 12. PMID 24270810, Free PMC Article
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC94361

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 46

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004201.1 → NP_001004201.1  leucine-rich repeat-containing protein 46

      See identical proteins and their annotated locations for NP_001004201.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079258
      UniProtKB/Swiss-Prot
      Q6AXZ2
      Conserved Domains (3) summary
      sd00031
      Location:50 → 71
      LRR_1; leucine-rich repeat [structural motif]
      pfam12799
      Location:71 → 110
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:70 → 126
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      82517767..82530011 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247268.5 → XP_006247330.1  leucine-rich repeat-containing protein 46 isoform X1

      See identical proteins and their annotated locations for XP_006247330.1

      UniProtKB/TrEMBL
      A6HII6
      Conserved Domains (2) summary
      sd00031
      Location:50 → 71
      LRR_1; leucine-rich repeat [structural motif]
      cd21340
      Location:60 → 177
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    2. XM_039085605.2 → XP_038941533.1  leucine-rich repeat-containing protein 46 isoform X2

      UniProtKB/TrEMBL
      G3V7B2
      Related
      ENSRNOP00000013542.4, ENSRNOT00000013542.6
      Conserved Domains (2) summary
      sd00031
      Location:20 → 41
      LRR_1; leucine-rich repeat [structural motif]
      cd21340
      Location:30 → 147
      PPP1R42; protein phosphatase 1 regulatory subunit 42
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AXZ2.1 GenPept UniProtKB/Swiss-Prot:Q6AXZ2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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