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    Nalf1 NALCN channel auxiliary factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 270028, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Nalf1provided by MGI
    Official Full Name
    NALCN channel auxiliary factor 1provided by MGI
    Primary source
    MGI:MGI:2142765
    See related
    Ensembl:ENSMUSG00000079157 AllianceGenome:MGI:2142765
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tmem28; Fam155a; 6430500D16
    Summary
    Predicted to contribute to stretch-activated, monoatomic cation-selective, calcium channel activity. Predicted to be involved in calcium ion import across plasma membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system and retina nuclear layer. Orthologous to human NALF1 (NALCN channel auxiliary factor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 4.6), cortex adult (RPKM 3.9) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nalf1 in Genome Data Viewer
    Location:
    8 A1.1; 8 3.9 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (9256006..9823329, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (9206006..9773329, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930453L07 gene Neighboring gene STARR-seq mESC enhancer starr_20682 Neighboring gene predicted gene, 31726 Neighboring gene predicted gene, 39128 Neighboring gene STARR-seq mESC enhancer starr_20686 Neighboring gene STARR-seq mESC enhancer starr_20687 Neighboring gene STARR-seq mESC enhancer starr_20688 Neighboring gene STARR-seq mESC enhancer starr_20691 Neighboring gene STARR-seq mESC enhancer starr_20692 Neighboring gene STARR-seq mESC enhancer starr_20693 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:9912234-9912417 Neighboring gene STARR-seq mESC enhancer starr_20694 Neighboring gene STARR-positive B cell enhancer ABC_E8225 Neighboring gene STARR-positive B cell enhancer ABC_E10489 Neighboring gene abhydrolase domain containing 13 Neighboring gene ligase IV, DNA, ATP-dependent

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Structure of voltage-modulated sodium-selective NALCN-FAM155A channel complex. Kang Y, et al. Nat Commun, 2020 Dec 3. PMID 33273469, Free PMC Article
    2. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    3. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structure of voltage-modulated sodium-selective NALCN-FAM155A channel complex.
      Title: Structure of voltage-modulated sodium-selective NALCN-FAM155A channel complex.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to stretch-activated, monoatomic cation-selective, calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    NALCN channel auxiliary factor 1
    Names
    family with sequence similarity 155, member A
    transmembrane protein 28
    transmembrane protein FAM155A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347127.1 → NP_001334056.1  NALCN channel auxiliary factor 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate exon which results in a different 3' coding region and UTR, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC099760, AK032202, AW121567, BC117535
      Consensus CDS
      CCDS85497.1
      UniProtKB/Swiss-Prot
      Q8CCS2
      Related
      ENSMUSP00000146609.2, ENSMUST00000208933.2
      Conserved Domains (1) summary
      pfam12929
      Location:278 → 323
      Mid1; Stretch-activated Ca2+-permeable channel component

    2. NM_173446.2 → NP_775622.1  NALCN channel auxiliary factor 1 isoform 1

      See identical proteins and their annotated locations for NP_775622.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC099760, AC107823
      Consensus CDS
      CCDS40216.1
      UniProtKB/Swiss-Prot
      Q149R3, Q8CCS2
      Related
      ENSMUSP00000106596.4, ENSMUST00000110969.5
      Conserved Domains (1) summary
      pfam12929
      Location:278 → 323
      Mid1; Stretch-activated Ca2+-permeable channel component

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      9256006..9823329 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242064.3 → XP_011240366.1  NALCN channel auxiliary factor 1 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CCS2.1 GenPept UniProtKB/Swiss-Prot:Q8CCS2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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