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    PRAS40 Proline-rich Akt substrate 40 kDa [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 26067067, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PRAS40provided by FlyBase
    Official Full Name
    Proline-rich Akt substrate 40 kDaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0267824
    Locus tag
    Dmel_CG46146
    See related
    AllianceGenome:FB:FBgn0267824
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10109; CG46146; Dmel\CG46146; dPRAS40; L
    Summary
    Involved in negative regulation of TORC1 signaling; negative regulation of insulin receptor signaling pathway; and negative regulation of vascular endothelial growth factor receptor signaling pathway. Located in cytosol. Is expressed in fat body; gonad; gut; and imaginal disc. Orthologous to human AKT1S1 (AKT1 substrate 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See PRAS40 in Genome Data Viewer
    Location:
    51A4-51A4; 2-71 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14481187..14497312)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Lobe Neighboring gene long non-coding RNA:CR44462 Neighboring gene Cleavage and polyadenylation specificity factor 160 Neighboring gene Additional sex combs

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NT_033778.4 Chromosome 2R Reference Release 6 plus ISO1 MT Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Classic Lobe Eye Phenotype of Drosophila Is Caused by Transposon Insertion-Induced Misexpression of a Zinc-Finger Transcription Factor. Son W, et al. Genetics, 2020 Sep. PMID 32641295, Free PMC Article
    2. Opposing interactions between homothorax and Lobe define the ventral eye margin of Drosophila eye. Singh A, et al. Dev Biol, 2011 Nov 15. PMID 21920354, Free PMC Article
    3. Dorso-ventral asymmetric functions of teashirt in Drosophila eye development depend on spatial cues provided by early DV patterning genes. Singh A, et al. Mech Dev, 2004 Apr. PMID 15110046
    4. Lobe mediates Notch signaling to control domain-specific growth in the Drosophila eye disc. Chern JJ, et al. Development, 2002 Sep. PMID 12163404
    5. Makorin 1 is required for Drosophila oogenesis by regulating insulin/Tor signaling. Jeong EB, et al. PLoS One, 2019. PMID 31009498, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in negative regulation of TOR signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of TOR signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of TORC1 signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of insulin receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in neurotrophin TRK receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    Proline-rich Akt substrate 40 kDa
    Names
    CG46146-PA
    PRAS40 ortholog
    PRAS40-PA
    lobe

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      14481187..14497312
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316420.1 → NP_001303349.1  Proline-rich Akt substrate 40 kDa [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JXA2
      Conserved Domains (1) summary
      pfam15798
      Location:472 → 556
      PRAS; Proline-rich AKT1 substrate 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JXA2 Q7JXA2

    Gene LinkOut

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