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    ysh1 cleavage and polyadenylation specificity factor complex endoribonuclease subunit Ysh1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542258, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ysh1
    Official Full Name
    cleavage and polyadenylation specificity factor complex endoribonuclease subunit Ysh1
    Primary source
    PomBase:SPAC17G6.16c
    Locus tag
    SPOM_SPAC17G6.16C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See ysh1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003424.3 (3620761..3623710, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene TREX complex subunit, ATP-dependent RNA helicase Uap56 Neighboring gene ncRNA Neighboring gene sideroflexin Fsf1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene LARP7 family RNA-binding protein Pof8/Lar7 Neighboring gene protein Rqc1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The conserved protein Seb1 drives transcription termination by binding RNA polymerase II and nascent RNA. Wittmann S, et al. Nat Commun, 2017 Apr 3. PMID 28367989, Free PMC Article
    2. CPF Recruitment to Non-canonical Transcription Termination Sites Triggers Heterochromatin Assembly and Gene Silencing. Vo TV, et al. Cell Rep, 2019 Jul 2. PMID 31269446, Free PMC Article
    3. A comparative analysis of an orthologous proteomic environment in the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe. Roguev A, et al. Mol Cell Proteomics, 2004 Feb. PMID 14617822
    4. The Nrd1-like protein Seb1 coordinates cotranscriptional 3' end processing and polyadenylation site selection. Lemay JF, et al. Genes Dev, 2016 Jul 1. PMID 27401558, Free PMC Article
    5. CPF-associated phosphatase activity opposes condensin-mediated chromosome condensation. Vanoosthuyse V, et al. PLoS Genet, 2014 Jun. PMID 24945319, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables 5'-3' RNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway IC
    Inferred by Curator
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    part_of mRNA cleavage and polyadenylation specificity factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mRNA cleavage and polyadenylation specificity factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    cleavage and polyadenylation specificity factor complex endoribonuclease subunit Ysh1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      3620761..3623710 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019686.3 → NP_594263.2  cleavage and polyadenylation specificity factor complex endoribonuclease subunit Ysh1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594263.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O13794
      Conserved Domains (5) summary
      smart01027
      Location:253 → 374
      Beta-Casp; Beta-Casp domain
      COG1236
      Location:19 → 462
      YSH1; RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]
      pfam07521
      Location:387 → 427
      RMMBL; RNA-metabolizing metallo-beta-lactamase
      pfam11718
      Location:484 → 650
      CPSF73-100_C; Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term
      cd16292
      Location:19 → 212
      CPSF3-like_MBL-fold; cleavage and polyadenylation specificity factor (CPSF) subunit 3 and related proteins; MBL-fold metallo-hydrolase domain
    Nucleotide Protein
    Heading Accession and Version

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