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    pso2 DNA 5' exonuclease [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541503, updated on 18-Sep-2024

    Summary

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    Official Symbol
    pso2
    Official Full Name
    DNA 5' exonuclease
    Primary source
    PomBase:SPAC22A12.01c
    Locus tag
    SPOM_SPAC22A12.01C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    snm1; SPAC56F8.17c
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    Genomic context

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    See pso2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (1156487..1159482, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene transcription factor Esc1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene protein mug103 Neighboring gene COP9/signalosome complex subunit Csn4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Schizosaccharomyces pombe checkpoint response to DNA interstrand cross-links. Lambert S, et al. Mol Cell Biol, 2003 Jul. PMID 12808110, Free PMC Article
    2. Nonhomologous End-Joining with Minimal Sequence Loss Is Promoted by the Mre11-Rad50-Nbs1-Ctp1 Complex in Schizosaccharomyces pombe. Li Y, et al. Genetics, 2017 May. PMID 28292918, Free PMC Article
    3. Crystal structure of a Fanconi anemia-associated nuclease homolog bound to 5' flap DNA: basis of interstrand cross-link repair by FAN1. Gwon GH, et al. Genes Dev, 2014 Oct 15. PMID 25319828, Free PMC Article
    4. RNA processing factors Swd2.2 and Sen1 antagonize RNA Pol III-dependent transcription and the localization of condensin at Pol III genes. Legros P, et al. PLoS Genet, 2014 Nov. PMID 25392932, Free PMC Article
    5. The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 ligase Pli1 act in two novel Pso2-independent pathways of DNA interstrand crosslink repair in yeast. Fontebasso Y, et al. DNA Repair (Amst), 2013 Dec. PMID 24192486, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables 5'-3' DNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables damaged DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via nonhomologous end joining IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in interstrand cross-link repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide-excision repair involved in interstrand cross-link repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    DNA 5' exonuclease

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      1156487..1159482 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018628.3 → NP_593231.2  DNA 5' exonuclease [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593231.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O13893, Q10264
      Conserved Domains (4) summary
      COG1236
      Location:44 → 518
      YSH1; RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]
      pfam07522
      Location:404 → 528
      DRMBL; DNA repair metallo-beta-lactamase
      pfam15926
      Location:32 → 148
      RNF220; E3 ubiquitin-protein ligase RNF220
      cd16273
      Location:175 → 332
      SNM1A-1C-like_MBL-fold; SNM1A , artemis/SNM1C, yeast Pso2p, and related proteins; MBL-fold metallo-hydrolase domain
    Nucleotide Protein
    Heading Accession and Version

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