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    alp5 Ino80, NuA4 and Swr1 complex actin-like protein Arp4 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541318, updated on 18-Sep-2024

    Summary

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    Official Symbol
    alp5
    Official Full Name
    Ino80, NuA4 and Swr1 complex actin-like protein Arp4
    Primary source
    PomBase:SPBP23A10.08
    Locus tag
    SPOM_SPBP23A10.08
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    arp4
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    Genomic context

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    See alp5 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (2012999..2015005)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene DNA-directed RNA polymerase I complex subunit Rpa2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene GINS complex subunit Psf1 Neighboring gene serine/threonine protein kinase Ppk32 Neighboring gene circularly permuted 1,3-beta-glucanase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Schizosaccharomyces pombe JmjC-protein, Msc1, prevents H2A.Z localization in centromeric and subtelomeric chromatin domains. Buchanan L, et al. PLoS Genet, 2009 Nov. PMID 19911051, Free PMC Article
    2. The INO80 complex activates the transcription of S-phase genes in a cell cycle-regulated manner. Knezevic I, et al. FEBS J, 2018 Oct. PMID 30134042
    3. BAF53/Arp4 homolog Alp5 in fission yeast is required for histone H4 acetylation, kinetochore-spindle attachment, and gene silencing at centromere. Minoda A, et al. Mol Biol Cell, 2005 Jan. PMID 15483052, Free PMC Article
    4. Histone variant H2A.Z regulates centromere silencing and chromosome segregation in fission yeast. Hou H, et al. J Biol Chem, 2010 Jan 15. PMID 19910462, Free PMC Article
    5. Fission yeast Iec1-ino80-mediated nucleosome eviction regulates nucleotide and phosphate metabolism. Hogan CJ, et al. Mol Cell Biol, 2010 Feb. PMID 19933844, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Alp5, an actin-related protein, is essential for histone H4 acetylation, the establishment of bipolar attachment of the kinetochore to the spindle, and transcriptional silencing at the centromere. [Alp5]
      Title: BAF53/Arp4 homolog Alp5 in fission yeast is required for histone H4 acetylation, kinetochore-spindle attachment, and gene silencing at centromere.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair-dependent chromatin remodeling IC
    Inferred by Curator
    more info
    		  
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription initiation-coupled chromatin remodeling IC
    Inferred by Curator
    more info
    		  
    Component Evidence Code Pubs
    part_of H4/H2A histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Ino80 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Ino80 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NuA4 histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Swr1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ino80, NuA4 and Swr1 complex actin-like protein Arp4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      2012999..2015005
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021724.3 → NP_595820.1  Ino80, NuA4 and Swr1 complex actin-like protein Arp4 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595820.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9P7X7
      Conserved Domains (2) summary
      COG5277
      Location:6 → 425
      COG5277; Actin-related protein [Cytoskeleton]
      pfam00022
      Location:11 → 433
      Actin; Actin
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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    Research Materials