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    txl1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541028, updated on 22-Aug-2024

    Summary

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    Official Symbol
    txl1
    Primary source
    PomBase:SPBC577.08c
    Locus tag
    SPOM_SPBC577.08C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    trx3
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    Genomic context

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    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003423.3 (766352..767490, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 1-phosphatidylinositol 4-kinase Stt4 Neighboring gene ubiquitin C-terminal hydrolase Ubp10 Neighboring gene ncRNA Neighboring gene DNA repair ERCC8 family protein ckn1 Neighboring gene proteasome core particle subunit beta 7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The txl1+ gene from Schizosaccharomyces pombe encodes a new thioredoxin-like 1 protein that participates in the antioxidant defence against tert-butyl hydroperoxide. Jiménez A, et al. Yeast, 2007 Jun. PMID 17476701
    2. Using in vivo oxidation status of one- and two-component redox relays to determine H(2)O(2) levels linked to signaling and toxicity. Domènech A, et al. BMC Biol, 2018 Jun 1. PMID 29859088, Free PMC Article
    3. Is oxidized thioredoxin a major trigger for cysteine oxidation? Clues from a redox proteomics approach. García-Santamarina S, et al. Antioxid Redox Signal, 2013 May 1. PMID 23121505, Free PMC Article
    4. Dissection of a redox relay: H2O2-dependent activation of the transcription factor Pap1 through the peroxidatic Tpx1-thioredoxin cycle. Calvo IA, et al. Cell Rep, 2013 Dec 12. PMID 24316080
    5. A peroxiredoxin promotes H2O2 signaling and oxidative stress resistance by oxidizing a thioredoxin family protein. Brown JD, et al. Cell Rep, 2013 Dec 12. PMID 24268782, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Txl1 and Txc1 are proteasome co-factors connected with oxidative stress.
      Title: Txl1 and Txc1 are co-factors of the 26S proteasome in fission yeast.
    2. role of txl1 in the cellular detoxification of alkyl hydroperoxide is exerted through a constitutive transcription of thioredoxin-like 1 protein
      Title: The txl1+ gene from Schizosaccharomyces pombe encodes a new thioredoxin-like 1 protein that participates in the antioxidant defence against tert-butyl hydroperoxide.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables protein-disulfide reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-disulfide reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-disulfide reductase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    thioredoxin-1-like protein Txl1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      766352..767490 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021213.3 → NP_595306.1  thioredoxin-1-like protein Txl1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595306.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9USR1
      Conserved Domains (2) summary
      cd02947
      Location:10 → 103
      TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
      pfam06201
      Location:129 → 275
      PITH; PITH domain
    Nucleotide Protein
    Heading Accession and Version

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