Adcy6 adenylate cyclase 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adcy6provided by RGD
Official Full Name: adenylate cyclase 6provided by RGD
Primary source: RGD:2035
See related: EnsemblRapid:ENSRNOG00000054757 AllianceGenome:RGD:2035
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: AC6; ACVI; ADCYB
Summary: Enables several functions, including SNARE binding activity; calcium- and calmodulin-responsive adenylate cyclase activity; and protein kinase binding activity. Involved in several processes, including cAMP biosynthetic process; maintenance of protein location in plasma membrane; and negative regulation of neuron projection development. Located in endosome; microvillus membrane; and sarcolemma. Biomarker of ureteral obstruction. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome. Orthologous to human ADCY6 (adenylate cyclase 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 205.1), Kidney (RPKM 181.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q36

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (131621860..131642923, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (129742827..129763922, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (140270678..140291722, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AC isoform, and not the others expressed in PC12 cells, may reside in a plasma membrane compartment that is uniquely accessible to the family B Gs-coupled GPCR PAC1.
Title: Cyclic Adenosine 3',5'-Monophosphate Elevation and Biological Signaling through a Secretin Family Gs-Coupled G Protein-Coupled Receptor Are Restricted to a Single Adenylate Cyclase Isoform.
Alteration of hormonal sensitivity of adenylyl cyclase in the brain of rats with prolonged streptozotocin diabetes.
Title: Alteration of hormonal sensitivity of adenylyl cyclase in the brain of rats with prolonged streptozotocin diabetes.
In primary hippocampal neurons and Neuro2A cells, elevated AC6 expression suppressed neurite outgrowth, whereas the downregulation or genetic removal of AC6 promoted neurite extension.
Title: Type VI adenylyl cyclase regulates neurite extension by binding to Snapin and Snap25.
AC6, but not the closely related AC5, plays a principal role in vasodilator signalling and regulation of the membrane potential in Vascular smooth muscle cells (VSMCs).
Title: Principal role of adenylyl cyclase 6 in K⁺ channel regulation and vasodilator signalling in vascular smooth muscle cells.
Increased expression of adenylyl cyclases V and VI is a major determinant of increased GABAergic transmission in the substantia nigra pars reticulata of animals in which L-DOPA induces severe dyskinesia.
Title: L-DOPA-induced dyskinesia in hemiparkinsonian rats is associated with up-regulation of adenylyl cyclase type V/VI and increased GABA release in the substantia nigra reticulata.
Isoproterenol activation of ACs promoted filamin phosphorylation, whereas thrombin inhibition of AC6 reduced filamin phosphorylation within the membrane fraction
Title: Filamin A is a phosphorylation target of membrane but not cytosolic adenylyl cyclase activity.
catalytically inactive mutant has same biological effects of intact enzyme, indicating that these effects do not require increased cAMP generation
Title: Beneficial effects of adenylyl cyclase type 6 (AC6) expression persist using a catalytically inactive AC6 mutant.
The distribution of Adenylyl cyclase type 6 to multiple cellular compartments appears to enable interactions with other proteins (e.g., PHLPP2) and activates cardioprotective signaling (PI3K/Akt).
Title: beta(1)-Adrenergic receptor vs adenylyl cyclase 6 expression in cardiac myocytes: differences in transgene localization and intracellular signaling.
increased expression of adenylyl cyclase VI activates Akt by phosphorylation at serine 473 and threonine 308 and is associated with increased nuclear phospho-Akt. Activated Akt phosphorylates phospholamban
Title: Adenylyl cyclase type VI increases Akt activity and phospholamban phosphorylation in cardiac myocytes.
AC6 is completely compartmentized in lipid raft domains where it is activated solely by coresident G protein-coupled receptors to regulate cardiac fibroblast function.
Title: Adenylyl cyclase type 6 overexpression selectively enhances beta-adrenergic and prostacyclin receptor-mediated inhibition of cardiac fibroblast function because of colocalization in lipid rafts.

Submit: New GeneRIF Correction See all GeneRIFs (16)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:532125

Cst3 (e-PCR), detects polymorphism
- UniSTS:532125

RH129348 (e-PCR)
- UniSTS:212655

RH127375 (e-PCR)
- UniSTS:210685

RH140859 (e-PCR)
- UniSTS:210685

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables SNARE binding	IDA Inferred from Direct Assay more info	PubMed
enables adenylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenylate cyclase activity	IDA Inferred from Direct Assay more info	PubMed
enables adenylate cyclase activity	IEA Inferred from Electronic Annotation more info
enables adenylate cyclase activity	ISO Inferred from Sequence Orthology more info
enables calcium- and calmodulin-responsive adenylate cyclase activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium- and calmodulin-responsive adenylate cyclase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein kinase C binding	IEA Inferred from Electronic Annotation more info
enables protein kinase C binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in adenylate cyclase-activating dopamine receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating dopamine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in blood vessel diameter maintenance	IEA Inferred from Electronic Annotation more info
involved_in blood vessel diameter maintenance	ISO Inferred from Sequence Orthology more info
involved_in cAMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cAMP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in cAMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cAMP biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cAMP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cellular response to catecholamine stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to forskolin	IEA Inferred from Electronic Annotation more info
involved_in cellular response to forskolin	ISO Inferred from Sequence Orthology more info
involved_in cellular response to forskolin	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to prostaglandin E stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to prostaglandin E stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to vasopressin	ISO Inferred from Sequence Orthology more info
involved_in cellular response to vasopressin	ISS Inferred from Sequence or Structural Similarity more info
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in maintenance of protein location in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of urine volume	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of urine volume	ISS Inferred from Sequence or Structural Similarity more info
involved_in renal water homeostasis	ISO Inferred from Sequence Orthology more info
involved_in renal water homeostasis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in microvillus membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
located_in stereocilium	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: adenylate cyclase type 6

Names: ATP pyrophosphate-lyase 6; adenylate cyclase type VI; adenylyl cyclase 6; ca(2+)-inhibitable adenylyl cyclase

NP_001257714.1

EC 4.6.1.1

NP_036953.5

EC 4.6.1.1

XP_017450158.1

EC 4.6.1.1

XP_017450159.1

EC 4.6.1.1

XP_038934384.1

EC 4.6.1.1

XP_038934385.1

EC 4.6.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001270785.1 → NP_001257714.1 adenylate cyclase type 6 isoform 1

See identical proteins and their annotated locations for NP_001257714.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

Q03343

UniProtKB/TrEMBL

A0A0G2K429, A6KC91

Related

ENSRNOP00000072881.1, ENSRNOT00000088323.3

Conserved Domains (4) summary

smart00044
Location:346 → 541

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:982 → 1176

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam06327
Location:594 → 680

DUF1053; Domain of Unknown Function (DUF1053)

pfam16214
Location:28 → 380

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
NM_012821.5 → NP_036953.5 adenylate cyclase type 6 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate first exon in place of that of exon 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

Q03343

UniProtKB/TrEMBL

A6KC93

Related

ENSRNOP00000078118.1, ENSRNOT00000109694.2

Conserved Domains (3) summary

pfam00211
Location:968 → 1162

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:14 → 366

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

pfam06327
Location:580 → 666

DUF1053; Domain of Unknown Function (DUF1053)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

131621860..131642923 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017594670.3 → XP_017450159.1 adenylate cyclase type 6 isoform X1

UniProtKB/Swiss-Prot

Q03343

UniProtKB/TrEMBL

A6KC93

Conserved Domains (3) summary

pfam00211
Location:968 → 1162

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:14 → 366

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

pfam06327
Location:580 → 666

DUF1053; Domain of Unknown Function (DUF1053)
XM_039078457.2 → XP_038934385.1 adenylate cyclase type 6 isoform X2

UniProtKB/Swiss-Prot

Q03343

Conserved Domains (3) summary

pfam00211
Location:964 → 1158

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:28 → 380

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

pfam06327
Location:576 → 662

DUF1053; Domain of Unknown Function (DUF1053)
XM_039078456.2 → XP_038934384.1 adenylate cyclase type 6 isoform X1

UniProtKB/Swiss-Prot

Q03343

UniProtKB/TrEMBL

A6KC93

Conserved Domains (3) summary

pfam00211
Location:968 → 1162

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:14 → 366

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

pfam06327
Location:580 → 666

DUF1053; Domain of Unknown Function (DUF1053)
XM_017594669.3 → XP_017450158.1 adenylate cyclase type 6 isoform X1

UniProtKB/Swiss-Prot

Q03343

UniProtKB/TrEMBL

A6KC93

Conserved Domains (3) summary

pfam00211
Location:968 → 1162

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:14 → 366

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

pfam06327
Location:580 → 666

DUF1053; Domain of Unknown Function (DUF1053)