Rgs9bp regulator of G-protein signalling 9 binding protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rgs9bpprovided by MGI
Official Full Name: regulator of G-protein signalling 9 binding proteinprovided by MGI
Primary source: MGI:MGI:2384418
See related: Ensembl:ENSMUSG00000056043 AllianceGenome:MGI:2384418
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: R9AP; Rgs9-1bp
Summary: Acts upstream of or within detection of light stimulus involved in visual perception. Predicted to be located in membrane. Predicted to be active in neuron projection. Is expressed in several structures, including olfactory epithelium and retina. Human ortholog(s) of this gene implicated in bradyopsia 2. Orthologous to human RGS9BP (regulator of G protein signaling 9 binding protein). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human all
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Genomic context

Location:: 7 B2; 7 21.37 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (35278418..35285007, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (35578993..35585582, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

R9AP is actively targeted in rods by its SNARE homology domain.
Title: R9AP targeting to rod outer segments is independent of rhodopsin and is guided by the SNARE homology domain.
the presence of a second, R9AP-expressing transgene in the iCre75 mouse line, leading to altered kinetics of phototransduction.
Title: R9AP overexpression alters phototransduction kinetics in iCre75 mice.
Under dim-light conditions vision is unaffected in transgenic mice overexpressing R9AP in rod photoreceptors.
Title: The relationship between slow photoresponse recovery rate and temporal resolution of vision.
Data report a surprising observation that the knockout of RGS9 causes a delay in ERG b-wave responses essentially identical to that observed in the R9AP knockout.
Title: RGS9 knockout causes a short delay in light responses of ON-bipolar cells.
This study indicated that R9AP is required for stable expression of RGS11-Gbeta5 in ON-bipolar cell dendrites.
Title: R9AP stabilizes RGS11-G beta5 and accelerates the early light response of ON-bipolar cells.
photoreceptors R9AP determines the stability of the RGS9.Gbeta5 complex, and therefore all three proteins, RGS9, Gbeta5 , and R9AP, are obligate members of the regulatory complex that speeds the rate at which transducin hydrolyzes GTP.
Title: Absence of the RGS9.Gbeta5 GTPase-activating complex in photoreceptors of the R9AP knockout mouse.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of light stimulus involved in visual perception	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within detection of light stimulus involved in visual perception	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	TAS Traceable Author Statement more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: regulator of G-protein signaling 9-binding protein

Names: RGS9 anchor protein; RGS9-1 anchor; RGS9-anchoring protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.