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    Slco5a1 solute carrier organic anion transporter family, member 5A1 [ Mus musculus (house mouse) ]

    Gene ID: 240726, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Slco5a1provided by MGI
    Official Full Name
    solute carrier organic anion transporter family, member 5A1provided by MGI
    Primary source
    MGI:MGI:2443431
    See related
    Ensembl:ENSMUSG00000025938 AllianceGenome:MGI:2443431
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4732454B15; A630033C23Rik
    Summary
    Predicted to enable sodium-independent organic anion transmembrane transporter activity. Predicted to be involved in sodium-independent organic anion transport. Predicted to be located in intracellular membrane-bounded organelle and plasma membrane. Predicted to be active in basolateral plasma membrane. Is expressed in several structures, including central nervous system; gonad; heart and pericardium; hemolymphoid system; and neural retina. Orthologous to human SLCO5A1 (solute carrier organic anion transporter family member 5A1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in whole brain E14.5 (RPKM 5.0), CNS E14 (RPKM 4.2) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slco5a1 in Genome Data Viewer
    Location:
    1 A3; 1 3.71 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (12936773..13063043, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (12866549..12992796, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 17644 Neighboring gene sulfatase 1 Neighboring gene STARR-seq mESC enhancer starr_00233 Neighboring gene STARR-seq mESC enhancer starr_00244 Neighboring gene STARR-positive B cell enhancer ABC_E1989 Neighboring gene STARR-seq mESC enhancer starr_00248 Neighboring gene STARR-seq mESC enhancer starr_00251 Neighboring gene STARR-seq mESC enhancer starr_00254 Neighboring gene STARR-seq mESC enhancer starr_00260 Neighboring gene STARR-seq mESC enhancer starr_00263 Neighboring gene developmental pluripotency associated 5A pseudogene Neighboring gene predicted gene, 39592

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The zinc finger SET domain gene Prdm14 is overexpressed in lymphoblastic lymphomas with retroviral insertions at Evi32. Dettman EJ, et al. PLoS One, 2008. PMID 19043588, Free PMC Article
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables sodium-independent organic anion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in sodium-independent organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier organic anion transporter family member 5A1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172841.2 → NP_766429.2  solute carrier organic anion transporter family member 5A1

      See identical proteins and their annotated locations for NP_766429.2

      Status: VALIDATED

      Source sequence(s)
      AC126044, AK041736, AV282837, AW490654, BQ031233
      Consensus CDS
      CCDS14821.2
      UniProtKB/TrEMBL
      E9PVD9
      Related
      ENSMUSP00000111062.3, ENSMUST00000115403.9
      Conserved Domains (1) summary
      cd17404
      Location:131 → 676
      MFS_SLCO5_OATP5; Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      12936773..13063043 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011238382.4 → XP_011236684.1  solute carrier organic anion transporter family member 5A1 isoform X2

      Conserved Domains (1) summary
      cd17404
      Location:131 → 621
      MFS_SLCO5_OATP5; Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters

    2. XM_011238380.4 → XP_011236682.1  solute carrier organic anion transporter family member 5A1 isoform X1

      See identical proteins and their annotated locations for XP_011236682.1

      UniProtKB/TrEMBL
      E9PVD9
      Related
      ENSMUSP00000140091.2, ENSMUST00000188454.7
      Conserved Domains (1) summary
      cd17404
      Location:131 → 676
      MFS_SLCO5_OATP5; Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters

    3. XM_030253982.1 → XP_030109842.1  solute carrier organic anion transporter family member 5A1 isoform X3

      Conserved Domains (1) summary
      cl28910
      Location:33 → 276
      MFS; Major Facilitator Superfamily

    4. XM_006495518.4 → XP_006495581.1  solute carrier organic anion transporter family member 5A1 isoform X4

      Conserved Domains (1) summary
      cl28910
      Location:28 → 271
      MFS; Major Facilitator Superfamily

    5. XM_011238381.4 → XP_011236683.1  solute carrier organic anion transporter family member 5A1 isoform X1

      See identical proteins and their annotated locations for XP_011236683.1

      UniProtKB/TrEMBL
      E9PVD9
      Conserved Domains (1) summary
      cd17404
      Location:131 → 676
      MFS_SLCO5_OATP5; Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters

    6. XM_030253981.2 → XP_030109841.1  solute carrier organic anion transporter family member 5A1 isoform X2

      Conserved Domains (1) summary
      cd17404
      Location:131 → 621
      MFS_SLCO5_OATP5; Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters

    7. XM_030253983.2 → XP_030109843.1  solute carrier organic anion transporter family member 5A1 isoform X3

      Conserved Domains (1) summary
      cl28910
      Location:33 → 276
      MFS; Major Facilitator Superfamily

    8. XM_030253984.2 → XP_030109844.1  solute carrier organic anion transporter family member 5A1 isoform X4

      Conserved Domains (1) summary
      cl28910
      Location:28 → 271
      MFS; Major Facilitator Superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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