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    Adgrg4 adhesion G protein-coupled receptor G4 [ Mus musculus (house mouse) ]

    Gene ID: 236798, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Adgrg4provided by MGI
    Official Full Name
    adhesion G protein-coupled receptor G4provided by MGI
    Primary source
    MGI:MGI:2685213
    See related
    Ensembl:ENSMUSG00000053852 AllianceGenome:MGI:2685213
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm367; PGR17; Gpr112
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human ADGRG4 (adhesion G protein-coupled receptor G4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Adgrg4 in Genome Data Viewer
    Location:
    X A6; X 30.34 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (55939594..56025719)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (56894234..56980359)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene four and a half LIM domains 1 Neighboring gene predicted gene, 23258 Neighboring gene STARR-seq mESC enhancer starr_47209 Neighboring gene MAP7 domain containing 3 Neighboring gene STARR-seq mESC enhancer starr_47210 Neighboring gene HIV TAT specific factor 1 Neighboring gene bombesin-like receptor 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Bjarnadóttir TK, et al. Genomics, 2004 Jul. PMID 15203201
    2. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. Hamann J, et al. Pharmacol Rev, 2015. PMID 25713288, Free PMC Article
    3. The G protein-coupled receptor repertoires of human and mouse. Vassilatis DK, et al. Proc Natl Acad Sci U S A, 2003 Apr 15. PMID 12679517, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neurogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    adhesion G-protein coupled receptor G4
    Names
    G protein coupled receptor Gpr112
    probable G-protein coupled receptor 112

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362885.1 → NP_001349814.1  adhesion G-protein coupled receptor G4

      Status: VALIDATED

      Source sequence(s)
      AL671998, AL672263
      UniProtKB/Swiss-Prot
      B7ZCC9, B7ZCD0
      Related
      ENSMUSP00000116634.2, ENSMUST00000153784.8
      Conserved Domains (4) summary
      pfam01825
      Location:2587 → 2629
      GPS; GPCR proteolysis site, GPS, motif
      cd15997
      Location:2642 → 2903
      7tmB2_GPR112; Probable G protein-coupled receptor 112, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      cl22861
      Location:54 → 162
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cl28246
      Location:276 → 746
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      55939594..56025719
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001033327.2: Suppressed sequence

      Description
      NM_001033327.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

    2. NM_001110790.1: Suppressed sequence

      Description
      NM_001110790.1: This RefSeq was temporarily suppressed because the CDS was partial.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7ZCC9.1 GenPept UniProtKB/Swiss-Prot:B7ZCC9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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