Asap3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Asap3provided by MGI
Official Full Name: ArfGAP with SH3 domain, ankyrin repeat and PH domain 3provided by MGI
Primary source: MGI:MGI:2684986
See related: Ensembl:ENSMUSG00000036995 AllianceGenome:MGI:2684986
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm140; UPLC1; Ddefl1; 9430088F20Rik
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in cell migration; positive regulation of GTPase activity; and regulation of stress fiber assembly. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in focal adhesion; intracellular membrane-bounded organelle; and ruffle. Orthologous to human ASAP3 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in limb E14.5 (RPKM 6.1), mammary gland adult (RPKM 3.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D3; 4 68.34 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (135933662..135973888)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (136206350..136246577)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ASAP3 functions nonredundantly with ASAP1 to control cell movement and may have a role in cancer cell invasion.
Title: ASAP3 is a focal adhesion-associated Arf GAP that functions in cell migration and invasion.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables GTPase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of stress fiber assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of stress fiber assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	ISS Inferred from Sequence or Structural Similarity more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in ruffle	IBA Inferred from Biological aspect of Ancestor more info
located_in ruffle	ISO Inferred from Sequence Orthology more info
located_in ruffle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3

Names: development and differentiation enhancing factor-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008232.2 → NP_001008233.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform 1

See identical proteins and their annotated locations for NP_001008233.1

Status: VALIDATED

Source sequence(s)

AL935264, BC085250

Consensus CDS

CCDS18802.1

UniProtKB/Swiss-Prot

Q5U464

Related

ENSMUSP00000041899.8, ENSMUST00000047526.8

Conserved Domains (7) summary

cd07640
Location:35 → 243

BAR_ASAP3; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 3

cd00204
Location:585 → 673

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd13251
Location:294 → 400

PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain

pfam00169
Location:307 → 390

PH; PH domain

pfam01412
Location:427 → 541

ArfGap; Putative GTPase activating protein for Arf

pfam13637
Location:588 → 641

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:550 → 583

ANK; ANK repeat [structural motif]
NM_001355698.1 → NP_001342627.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform 2

Status: VALIDATED

Source sequence(s)

AL935264, BC085250

Conserved Domains (4) summary

cd00204
Location:312 → 400

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd13251
Location:21 → 127

PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain

sd00045
Location:277 → 310

ANK; ANK repeat [structural motif]

pfam01412
Location:154 → 268

ArfGap; Putative GTPase activating protein for Arf

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

135933662..135973888

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006538761.3 → XP_006538824.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X1

Conserved Domains (5) summary

cd07640
Location:2 → 209

BAR_ASAP3; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 3

COG0666
Location:549 → 646

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd13251
Location:260 → 366

PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain

sd00045
Location:516 → 549

ANK; ANK repeat [structural motif]

cd17900
Location:389 → 512

ArfGap_ASAP3; ArfGAP domain of ASAP3 (ArfGAP with ANK repeat and PH domain-containing protein 3)
XM_011250233.4 → XP_011248535.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X2

Conserved Domains (5) summary

COG0666
Location:542 → 639

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd13251
Location:253 → 359

PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain

sd00045
Location:509 → 542

ANK; ANK repeat [structural motif]

cd17900
Location:382 → 505

ArfGap_ASAP3; ArfGAP domain of ASAP3 (ArfGAP with ANK repeat and PH domain-containing protein 3)

cl12013
Location:3 → 202

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature