Zp1 zona pellucida glycoprotein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zp1provided by MGI
Official Full Name: zona pellucida glycoprotein 1provided by MGI
Primary source: MGI:MGI:103073
See related: Ensembl:ENSMUSG00000024734 AllianceGenome:MGI:103073
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable acrosin binding activity. Predicted to be a structural constituent of egg coat. Predicted to be involved in binding activity of sperm to zona pellucida and prevention of polyspermy. Located in collagen-containing extracellular matrix. Is expressed in early conceptus; ovary; and secondary oocyte. Orthologous to human ZP1 (zona pellucida glycoprotein 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Restricted expression toward ovary adult (RPKM 22.1) See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 7.36 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (10891660..10897965, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (10914296..10920601, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Influence of mouse defective zona pellucida in folliculogenesis on apoptosis of granulosa cells and developmental competence of oocytesdagger.
Title: Influence of mouse defective zona pellucida in folliculogenesis on apoptosis of granulosa cells and developmental competence of oocytes†.
characterization of native mouse zona pellucida proteins by mass spectrometry
Title: Structural characterization of native mouse zona pellucida proteins using mass spectrometry.
stoichiometric disposition of ZP1, ZP2, and ZP3 in the ovarian zona matrix revealed by double and triple immunolocalization studies
Title: Subcellular distribution of ZP1, ZP2, and ZP3 glycoproteins during folliculogenesis and demonstration of their topographical disposition within the zona matrix of mouse ovarian oocytes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

General gene information

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Markers

Zp1 (e-PCR), detects polymorphism
- UniSTS:498287

Zp1 (e-PCR), detects polymorphism
- UniSTS:525727

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acrosin binding	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of egg coat	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of egg coat	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in binding of sperm to zona pellucida	IBA Inferred from Biological aspect of Ancestor more info
involved_in prevention of polyspermy	IBA Inferred from Biological aspect of Ancestor more info
involved_in single fertilization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in collagen-containing extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
is_active_in egg coat	IBA Inferred from Biological aspect of Ancestor more info
located_in egg coat	ISO Inferred from Sequence Orthology more info
located_in egg coat	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zona pellucida sperm-binding protein 1

Names: zp-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009580.2 → NP_033606.2 zona pellucida sperm-binding protein 1 precursor

See identical proteins and their annotated locations for NP_033606.2

Status: VALIDATED

Source sequence(s)

BC125613

Consensus CDS

CCDS37918.1

UniProtKB/Swiss-Prot

Q62005, Q62016

UniProtKB/TrEMBL

Q059L1

Related

ENSMUSP00000025641.2, ENSMUST00000025641.2

Conserved Domains (3) summary

smart00018
Location:226 → 268

PD; P or trefoil or TFF domain

smart00241
Location:271 → 541

ZP; Zona pellucida (ZP) domain

pfam00100
Location:404 → 539

Zona_pellucida; Zona pellucida-like domain