Prss2 serine protease 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prss2provided by MGI
Official Full Name: serine protease 2provided by MGI
Primary source: MGI:MGI:102759
See related: Ensembl:ENSMUSG00000057163 AllianceGenome:MGI:102759
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ta; TRY8; TRYP; Try2; Tesp4
Summary: Enables serine-type endopeptidase activity. Predicted to be involved in several processes, including collagen catabolic process; response to caffeine; and response to nicotine. Located in collagen-containing extracellular matrix. Is expressed in alimentary system; genitourinary system; and spleen. Orthologous to human PRSS2 (serine protease 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: 6 B1; 6 19.67 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (41498710..41502013)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (41521776..41525079)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PRSS2 overexpression relates to poor prognosis and promotes proliferation, migration and invasion in gastric cancer.
Title: PRSS2 overexpression relates to poor prognosis and promotes proliferation, migration and invasion in gastric cancer.
up-regulation of trypsins is one of the key host pathological findings in influenza A-induced myocarditis
Title: Up-regulation of ectopic trypsins in the myocardium by influenza A virus infection triggers acute myocarditis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in collagen catabolic process	ISO Inferred from Sequence Orthology more info
involved_in collagen catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in digestion	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to acetaldehyde	IEA Inferred from Electronic Annotation more info
involved_in response to caffeine	IEA Inferred from Electronic Annotation more info
involved_in response to caffeine	ISO Inferred from Sequence Orthology more info
involved_in response to nicotine	IEA Inferred from Electronic Annotation more info
involved_in response to nicotine	ISO Inferred from Sequence Orthology more info
involved_in response to nutrient	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: anionic trypsin-2

Names: anionic trypsin II; pretrypsinogen II; protease, serine 2; trypsin 2; trypsinogen 20

NP_033456.1

EC 3.4.21.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_006980.1

Range

630982..634285

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_009430.2 → NP_033456.1 anionic trypsin-2 precursor

See identical proteins and their annotated locations for NP_033456.1

Status: VALIDATED

Source sequence(s)

AK003082, BB841364

Consensus CDS

CCDS20050.1

UniProtKB/Swiss-Prot

P07146

UniProtKB/TrEMBL

Q3V2E0, Q792Y6

Related

ENSMUSP00000065393.5, ENSMUST00000070380.5

Conserved Domains (2) summary

smart00020
Location:23 → 239

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:24 → 242

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...