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    Arap2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 [ Mus musculus (house mouse) ]

    Gene ID: 212285, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Arap2provided by MGI
    Official Full Name
    ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2provided by MGI
    Primary source
    MGI:MGI:2684416
    See related
    Ensembl:ENSMUSG00000037999 AllianceGenome:MGI:2684416
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm148; Centd1; mKIAA0580
    Summary
    Predicted to enable GTPase activator activity and phosphatidylinositol-3,4,5-trisphosphate binding activity. Predicted to be involved in regulation of actin cytoskeleton organization. Predicted to be active in cytoplasm. Orthologous to human ARAP2 (ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cortex adult (RPKM 7.0), frontal lobe adult (RPKM 6.3) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Arap2 in Genome Data Viewer
    Location:
    5 C3.1; 5 32.04 cM
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (62759788..62923874, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (62602445..62766192, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13167 Neighboring gene STARR-seq mESC enhancer starr_13168 Neighboring gene predicted gene, 22273 Neighboring gene STARR-seq mESC enhancer starr_13169 Neighboring gene STARR-seq mESC enhancer starr_13170 Neighboring gene predicted gene, 24079 Neighboring gene STARR-seq mESC enhancer starr_13171 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:63169898-63170155 Neighboring gene STARR-seq mESC enhancer starr_13172 Neighboring gene STARR-seq mESC enhancer starr_13173 Neighboring gene STARR-positive B cell enhancer ABC_E11287 Neighboring gene STARR-seq mESC enhancer starr_13174 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:63249548-63249756 Neighboring gene death domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_13175 Neighboring gene STARR-seq mESC enhancer starr_13176 Neighboring gene STARR-seq mESC enhancer starr_13177 Neighboring gene predicted gene, 30837

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of radiation-responsive genes in vitro using a gene trap strategy predicts for modulation of expression by radiation in vivo. Vallis KA, et al. Radiat Res, 2002 Jan. PMID 11754636
    2. ARAP2 promotes GLUT1-mediated basal glucose uptake through regulation of sphingolipid metabolism. Chaudhari A, et al. Biochim Biophys Acta, 2016 Nov. PMID 27476102
    3. PI3K signaling through the dual GTPase-activating protein ARAP3 is essential for developmental angiogenesis. Gambardella L, et al. Sci Signal, 2010 Oct 26. PMID 20978237
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
    5. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1)  1 citation
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2
    Names
    PARX protein
    centaurin, delta 1
    cnt-d1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178407.3 → NP_848494.2  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2

      See identical proteins and their annotated locations for NP_848494.2

      Status: VALIDATED

      Source sequence(s)
      AC122231, AC124720, AC135359
      Consensus CDS
      CCDS51506.1
      UniProtKB/Swiss-Prot
      Q80TX2, Q8BZ05, Q8C3T2, Q8VEL6
      UniProtKB/TrEMBL
      E9QP44
      Related
      ENSMUSP00000075924.5, ENSMUST00000076623.8
      Conserved Domains (8) summary
      cd09490
      Location:6 → 68
      SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
      cd04385
      Location:1112 → 1291
      RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
      cd13253
      Location:482 → 573
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:583 → 673
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd13256
      Location:890 → 1000
      PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3
      cd17227
      Location:1323 → 1420
      RA_ARAP2; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 (ARAP2)
      cd08856
      Location:678 → 798
      ArfGap_ARAP2; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 2
      cl17171
      Location:1426 → 1537
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      62759788..62923874 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164979.1 → XP_036020872.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X4

      UniProtKB/Swiss-Prot
      Q80TX2, Q8BZ05, Q8C3T2, Q8VEL6
      Conserved Domains (8) summary
      cd09490
      Location:6 → 68
      SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
      cd04385
      Location:1112 → 1291
      RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
      cd13253
      Location:482 → 573
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:583 → 673
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd13256
      Location:890 → 1000
      PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3
      cd08856
      Location:678 → 798
      ArfGap_ARAP2; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 2
      cl17171
      Location:1378 → 1489
      PH-like; Pleckstrin homology-like domain
      cl28922
      Location:1287 → 1372
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    2. XM_030254348.2 → XP_030110208.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X5

      UniProtKB/Swiss-Prot
      Q80TX2, Q8BZ05, Q8C3T2, Q8VEL6
      Conserved Domains (8) summary
      cd09490
      Location:6 → 68
      SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
      cd04385
      Location:1112 → 1291
      RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
      cd13253
      Location:482 → 573
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:583 → 673
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd13256
      Location:890 → 1000
      PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3
      cd17227
      Location:1300 → 1397
      RA_ARAP2; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 (ARAP2)
      cd08856
      Location:678 → 798
      ArfGap_ARAP2; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 2
      cl17171
      Location:1403 → 1507
      PH-like; Pleckstrin homology-like domain

    3. XM_006503828.5 → XP_006503891.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006503891.1

      UniProtKB/Swiss-Prot
      Q80TX2, Q8BZ05, Q8C3T2, Q8VEL6
      Conserved Domains (8) summary
      cd09490
      Location:6 → 68
      SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
      cd04385
      Location:1112 → 1291
      RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
      cd13253
      Location:482 → 573
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:583 → 673
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd13256
      Location:890 → 1000
      PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3
      cd17227
      Location:1300 → 1397
      RA_ARAP2; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 (ARAP2)
      cd08856
      Location:678 → 798
      ArfGap_ARAP2; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 2
      cl17171
      Location:1403 → 1514
      PH-like; Pleckstrin homology-like domain

    4. XM_006503829.4 → XP_006503892.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X3

      UniProtKB/Swiss-Prot
      Q80TX2, Q8BZ05, Q8C3T2, Q8VEL6
      Conserved Domains (8) summary
      cd09490
      Location:6 → 68
      SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
      cd04385
      Location:1112 → 1291
      RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
      cd13253
      Location:482 → 573
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:583 → 673
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd13256
      Location:890 → 1000
      PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3
      cd17227
      Location:1323 → 1420
      RA_ARAP2; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 (ARAP2)
      cd08856
      Location:678 → 798
      ArfGap_ARAP2; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 2
      cl17171
      Location:1426 → 1530
      PH-like; Pleckstrin homology-like domain

    5. XM_011240712.4 → XP_011239014.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011239014.1

      UniProtKB/Swiss-Prot
      Q80TX2, Q8BZ05, Q8C3T2, Q8VEL6
      UniProtKB/TrEMBL
      E9QP44
      Conserved Domains (8) summary
      cd09490
      Location:6 → 68
      SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
      cd04385
      Location:1112 → 1291
      RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
      cd13253
      Location:482 → 573
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:583 → 673
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd13256
      Location:890 → 1000
      PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3
      cd17227
      Location:1323 → 1420
      RA_ARAP2; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 (ARAP2)
      cd08856
      Location:678 → 798
      ArfGap_ARAP2; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 2
      cl17171
      Location:1426 → 1537
      PH-like; Pleckstrin homology-like domain

    6. XM_036164980.1 → XP_036020873.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X6

      Conserved Domains (5) summary
      cd09490
      Location:6 → 68
      SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
      cd13253
      Location:482 → 573
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:583 → 673
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd08856
      Location:678 → 798
      ArfGap_ARAP2; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 2
      cl17171
      Location:890 → 964
      PH-like; Pleckstrin homology-like domain

    RNA

    1. XR_003955612.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BZ05.2 GenPept UniProtKB/Swiss-Prot:Q8BZ05

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