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    gcy-21 Receptor-type guanylate cyclase gcy-21 [ Caenorhabditis elegans ]

    Gene ID: 191651, updated on 2-Nov-2024

    Summary

    Official Symbol
    gcy-21
    Official Full Name
    Receptor-type guanylate cyclase gcy-21
    Primary source
    WormBase:WBGene00001546
    Locus tag
    CELE_F22E5.3
    See related
    AllianceGenome:WB:WBGene00001546
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable guanylate cyclase activity and peptide receptor activity. Predicted to be involved in cGMP biosynthetic process and receptor guanylyl cyclase signaling pathway. Predicted to be active in plasma membrane. Is expressed in amphid neurons. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See gcy-21 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    17
    Sequence:
    Chromosome: II; NC_003280.10 (2659664..2664686)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class T Neighboring gene pseudo Neighboring gene Secreted protein Neighboring gene Uncharacterized protein Neighboring gene Serpentine Receptor, class I

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables guanylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cGMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cGMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cyclic nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in receptor guanylyl cyclase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Receptor-type guanylate cyclase gcy-21
    NP_001364740.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      2659664..2664686
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001377729.2NP_001364740.1  Receptor-type guanylate cyclase gcy-21 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O16715
      Conserved Domains (4) summary
      cd13992
      Location:612881
      PK_GC; Pseudokinase domain of membrane Guanylate Cyclase receptors
      pfam00211
      Location:9441130
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07701
      Location:890938
      HNOBA; Heme NO binding associated
      cl10011
      Location:58422
      Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily