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    Ahnak AHNAK nucleoprotein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 191572, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ahnakprovided by RGD
    Official Full Name
    AHNAK nucleoproteinprovided by RGD
    Primary source
    RGD:619779
    See related
    EnsemblRapid:ENSRNOG00000057569 AllianceGenome:RGD:619779
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    UV118; AHNAK 1; RGD1308572
    Summary
    Predicted to enable S100 protein binding activity; identical protein binding activity; and structural molecule activity conferring elasticity. Predicted to be involved in regulation of RNA splicing and regulation of voltage-gated calcium channel activity. Predicted to be located in several cellular components, including costamere; extracellular exosome; and sarcolemma. Predicted to be part of plasma membrane protein complex. Used to study autoimmune disease. Orthologous to human AHNAK (AHNAK nucleoprotein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 7148.3), Heart (RPKM 4500.7) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ahnak in Genome Data Viewer
    Location:
    1q43
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (215311289..215400010)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (205882225..205970934)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (225184883..225429638)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483968 Neighboring gene terminal uridylyl transferase 1, U6 snRNA-specific Neighboring gene eukaryotic translation elongation factor 1 gamma Neighboring gene U4 spliceosomal RNA Neighboring gene ribosomal protein L7a, pseudogene 8 Neighboring gene secretoglobin family 1A member 1 Neighboring gene asparaginase and isoaspartyl peptidase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of AHNAK as a novel autoantigen in systemic lupus erythematosus. Sköldberg F, et al. Biochem Biophys Res Commun, 2002 Mar 8. PMID 11866458
    2. Regulated exocytosis: a novel, widely expressed system. Borgonovo B, et al. Nat Cell Biol, 2002 Dec. PMID 12447386
    3. Calcium current in rat cardiomyocytes is modulated by the carboxyl-terminal ahnak domain. Alvarez J, et al. J Biol Chem, 2004 Mar 26. PMID 14722071
    4. Spinal cord injury-induced up-regulation of AHNAK, expressed in cells delineating cystic cavities, and associated with neoangiogenesis. von Boxberg Y, et al. Eur J Neurosci, 2006 Aug. PMID 16930430
    5. The giant protein AHNAK involved in morphogenesis and laminin substrate adhesion of myelinating Schwann cells. Salim C, et al. Glia, 2009 Apr 1. PMID 18837049

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. our results clearly show the implication of AHNAK in myelinating Schwann cell adhesion to laminin, probably via targeting of the dystroglycan-associated receptor complex
      Title: The giant protein AHNAK involved in morphogenesis and laminin substrate adhesion of myelinating Schwann cells.
    2. Results suggest that AHNAK expression is associated with cell types displaying tissue-protective barrier properties, and with neoangiogenesis, following spinal cord injury.
      Title: Spinal cord injury-induced up-regulation of AHNAK, expressed in cells delineating cystic cavities, and associated with neoangiogenesis.
    3. AHNAK has a role in modulating calcium current in rat cardiomyocyte
      Title: Calcium current in rat cardiomyocytes is modulated by the carboxyl-terminal ahnak domain.
    4. Ahnak has a critical role in cardiac Ca(V)1.2 calcium channel function and its beta-adrenergic regulation
      Title: Ahnak is critical for cardiac Ca(V)1.2 calcium channel function and its beta-adrenergic regulation.
    5. The carboxyl-terminal ahnak domain exerts a stabilizing effect on muscle contractility via its interaction with actin of thin filaments.
      Title: The carboxyl-terminal ahnak domain induces actin bundling and stabilizes muscle contraction.
    6. a marker of an extensive form of calcium-induced exocytosis
      Title: Regulated exocytosis: a novel, widely expressed system.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables S100 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables structural molecule activity conferring elasticity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables structural molecule activity conferring elasticity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of RNA splicing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of voltage-gated calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of voltage-gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in actin cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cell-cell contact zone ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell-cell contact zone ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in costamere ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in costamere ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane raft ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of plasma membrane protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sarcolemma ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    neuroblast differentiation-associated protein AHNAK
    Names
    desmoyokin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398671.1 → NP_001385600.1  neuroblast differentiation-associated protein AHNAK isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      Related
      ENSRNOP00000102284.1, ENSRNOT00000130158.1
      Conserved Domains (3) summary
      COG2911
      Location:2614 → 2920
      TamB; Autotransporter translocation and assembly factor TamB [Intracellular trafficking, secretion, and vesicular transport]
      pfam05109
      Location:4578 → 4776
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl00117
      Location:23 → 91
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...

    2. NM_001398672.1 → NP_001385601.1  neuroblast differentiation-associated protein AHNAK isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      Related
      ENSRNOP00000098820.1, ENSRNOT00000134873.1
      Conserved Domains (1) summary
      cl00117
      Location:23 → 91
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      215311289..215400010
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017588769.3 → XP_017444258.1  neuroblast differentiation-associated protein AHNAK isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZUE6, A6HZY5, A6HZY6
      Related
      ENSRNOP00000081127.2, ENSRNOT00000112370.2
      Conserved Domains (1) summary
      cl00117
      Location:23 → 91
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...

    2. XM_063278638.1 → XP_063134708.1  neuroblast differentiation-associated protein AHNAK isoform X1

    RNA

    1. XR_005492950.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001191951.1: Suppressed sequence

      Description
      NM_001191951.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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