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    Y56A3A.16 Rubicon Homology domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 190329, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Y56A3A.16
    Official Full Name
    Rubicon Homology domain-containing protein
    Primary source
    WormBase:WBGene00013235
    Locus tag
    CELE_Y56A3A.16
    See related
    AllianceGenome:WB:WBGene00013235
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable phosphatidylinositol phosphate binding activity. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in intestine; neurons; and pharynx. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 15. Orthologous to human RUBCN (rubicon autophagy regulator) and RUBCNL (rubicon like autophagy enhancer). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See Y56A3A.16 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (11910176..11914320, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene F-box associated domain-containing protein Neighboring gene F-box domain-containing protein Neighboring gene Acyl carrier protein Neighboring gene Nuclear pore complex protein npp-16 Neighboring gene Zinc finger protein 593 homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Suppression of autophagic activity by Rubicon is a signature of aging. Nakamura S, et al. Nat Commun, 2019 Feb 19. PMID 30783089, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Y56A3A.16 (Rubicon) negatively regulates autophagy.
      Title: Suppression of autophagic activity by Rubicon is a signature of aging.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables phosphatidylinositol phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Rubicon Homology domain-containing protein
    NP_001255146.1
    • Confirmed by transcript evidence
    NP_001255147.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      11910176..11914320 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268218.2 → NP_001255147.1  Rubicon Homology domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255147.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G2HK09
      Conserved Domains (1) summary
      pfam13901
      Location:366 → 577
      zf-RING_9; Putative zinc-RING and/or ribbon

    2. NM_001268217.3 → NP_001255146.1  Rubicon Homology domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255146.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G2HK08
      Conserved Domains (1) summary
      pfam13901
      Location:366 → 575
      zf-RING_9; Putative zinc-RING and/or ribbon
    Nucleotide Protein
    Heading Accession and Version

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