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    mpst-7 Rhodanese domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 187919, updated on 2-Nov-2024

    Summary

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    Official Symbol
    mpst-7
    Official Full Name
    Rhodanese domain-containing protein
    Primary source
    WormBase:WBGene00011307
    Locus tag
    CELE_R186.6
    See related
    AllianceGenome:WB:WBGene00011307
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 3-mercaptopyruvate sulfurtransferase activity and thiosulfate sulfurtransferase activity. Predicted to be located in membrane. Predicted to be active in mitochondrion. Orthologous to several human genes including MPST (mercaptopyruvate sulfurtransferase). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See mpst-7 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (12955210..12961135, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene D-aminoacyl-tRNA deacylase Neighboring gene Eukaryotic translation initiation factor 3 subunit K Neighboring gene ncRNA Neighboring gene Transport and Golgi organization protein 2 homolog Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein;Serpentine Receptor, class D (delta)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. HIF-1 Has a Central Role in Caenorhabditis elegans Organismal Response to Selenium. Romanelli-Credrez L, et al. Front Genet, 2020. PMID 32161616, Free PMC Article
    2. Sulfurous gases as biological messengers and toxins: comparative genetics of their metabolism in model organisms. Mathew ND, et al. J Toxicol, 2011. PMID 22131987, Free PMC Article
    3. Increasing Complexity of the N-Glycome During Caenorhabditis Development. Wilson IBH, et al. Mol Cell Proteomics, 2023 Mar. PMID 36717059, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 3-mercaptopyruvate sulfurtransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sulfurtransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thiosulfate sulfurtransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Rhodanese domain-containing protein
    NP_506242.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      12955210..12961135 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073841.5 → NP_506242.2  Rhodanese domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506242.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EEV0
      Conserved Domains (3) summary
      COG2897
      Location:173 → 409
      SseA; 3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains [Inorganic ion transport and metabolism]
      cd01448
      Location:146 → 260
      TST_Repeat_1; Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it ...
      cl00125
      Location:293 → 404
      RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...
    Nucleotide Protein
    Heading Accession and Version

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