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    ech-9 Enoyl-CoA Hydratase [ Caenorhabditis elegans ]

    Gene ID: 184065, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ech-9
    Official Full Name
    Enoyl-CoA Hydratase
    Primary source
    WormBase:WBGene00001158
    Locus tag
    CELE_F01G10.3
    See related
    AllianceGenome:WB:WBGene00001158
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 3-hydroxyacyl-CoA dehydrogenase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to be active in peroxisome. Human ortholog(s) of this gene implicated in Fanconi renotubular syndrome 3. Orthologous to human EHHADH (enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See ech-9 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    8
    Sequence:
    Chromosome: IV; NC_003282.8 (10233310..10235329, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene HOOK_N domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene Enoyl-CoA Hydratase Neighboring gene Lipase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PQM-1 controls hypoxic survival via regulation of lipid metabolism. Heimbucher T, et al. Nat Commun, 2020 Oct 2. PMID 33009389, Free PMC Article
    2. Remofuscin induces xenobiotic detoxification via a lysosome-to-nucleus signaling pathway to extend the Caenorhabditis elegans lifespan. Oh M, et al. Sci Rep, 2022 May 3. PMID 35504961, Free PMC Article
    3. Mutation in Caenorhabditis elegans Krüppel-like factor, KLF-3 results in fat accumulation and alters fatty acid composition. Zhang J, et al. Exp Cell Res, 2009 Sep 10. PMID 19427851
    4. Rege-1 promotes C. elegans survival by modulating IIS and TOR pathways. Tsai YT, et al. PLoS Genet, 2023 Aug. PMID 37556491, Free PMC Article
    5. A Mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and -independent pathways in C. elegans. Taubert S, et al. Genes Dev, 2006 May 1. PMID 16651656, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 3-hydroxyacyl-CoA dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+ binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Enoyl-CoA Hydratase
    NP_001368477.1
    • Product from WormBase gene class ech;
      Confirmed by transcript evidence
    NP_501875.2
    • Product from WormBase gene class ech;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      10233310..10235329 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069474.6 → NP_501875.2  Enoyl-CoA Hydratase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501875.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O17762
      Conserved Domains (3) summary
      COG1250
      Location:38 → 317
      FadB; 3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]
      pfam00725
      Location:220 → 307
      3HCDH; 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
      pfam02737
      Location:41 → 217
      3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain

    2. NM_001380437.1 → NP_001368477.1  Enoyl-CoA Hydratase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061AKU6
      Conserved Domains (1) summary
      COG1250
      Location:26 → 305
      FadB; 3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version

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