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    cdr-2 CaDmium Responsive [ Caenorhabditis elegans ]

    Gene ID: 183779, updated on 2-Nov-2024

    Summary

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    Official Symbol
    cdr-2
    Official Full Name
    CaDmium Responsive
    Primary source
    WormBase:WBGene00008296
    Locus tag
    CELE_C54D10.1
    See related
    AllianceGenome:WB:WBGene00008296
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in regulation of protein deneddylation and stress response to cadmium ion. Predicted to be located in membrane. Predicted to be active in cytoplasm. Is expressed in nervous system; pharynx; rectal epithelium; and reproductive system. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See cdr-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (12414656..12415709, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene CaDmium Responsive Neighboring gene CaDmium Responsive Neighboring gene CaDmium Responsive Neighboring gene ShKT domain-containing protein Neighboring gene RDS/peripherin-like protein xRDS35

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A cadmium toxicity assay using stress responsive Caenorhabditis elegans mutant strains. Roh JY, et al. Environ Toxicol Pharmacol, 2009 Nov. PMID 21784035
    2. Identification and characterization of a family of Caenorhabditis elegans genes that is homologous to the cadmium-responsive gene cdr-1. Dong J, et al. Biochim Biophys Acta, 2005 Jan 21. PMID 15652154
    3. Molecular strategies of the Caenorhabditis elegans dauer larva to survive extreme desiccation. Erkut C, et al. PLoS One, 2013. PMID 24324795, Free PMC Article
    4. Reduced bone morphogenic protein signaling along the gut-neuron axis by heat shock factor promotes longevity. Arneaud SLB, et al. Aging Cell, 2022 Sep. PMID 35977034, Free PMC Article
    5. Using RNA interference to identify specific modifiers of a temperature-sensitive, embryonic-lethal mutation in the Caenorhabditis elegans ubiquitin-like Nedd8 protein modification pathway E1-activating gene rfl-1. Dorfman M, et al. Genetics, 2009 Aug. PMID 19528325, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in regulation of protein deneddylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in stress response to cadmium ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in stress response to cadmium ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CaDmium Responsive
    NP_506114.1
    • Product from WormBase gene class cdr;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      12414656..12415709 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073713.5 → NP_506114.1  CaDmium Responsive [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506114.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECX9
      Conserved Domains (3) summary
      cd03193
      Location:198 → 268
      GST_C_Metaxin; C-terminal, alpha helical domain of Metaxin and related proteins
      COG0625
      Location:59 → 269
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cd03080
      Location:46 → 117
      GST_N_Metaxin_like; GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It ...
    Nucleotide Protein
    Heading Accession and Version

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