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    aqp-7 Aquaporin-9 [ Caenorhabditis elegans ]

    Gene ID: 180589, updated on 19-Jun-2024

    Summary

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    Gene symbol
    aqp-7
    Gene description
    Aquaporin-9
    Locus tag
    CELE_M02F4.8
    See related
    AllianceGenome:WB:WBGene00000175
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables water channel activity. Involved in glycerol transport and water transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in basolateral plasma membrane. Is expressed in muscle cell. Human ortholog(s) of this gene implicated in kidney disease. Orthologous to human AQP3 (aquaporin 3 (Gill blood group)) and AQP9 (aquaporin 9). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See aqp-7 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    6
    Sequence:
    Chromosome: X; NC_003284.9 (3025125..3026872)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene SVPGVLRF-amide 3 Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Improved method for visualizing cells revealed dynamic morphological changes of ventral neuroblasts during ventral cleft closure of Caenorhabditis elegans. Liu Z, et al. Dev Growth Differ, 2007 Jan. PMID 17227344
    2. Functional analysis of the aquaporin gene family in Caenorhabditis elegans. Huang CG, et al. Am J Physiol Cell Physiol, 2007 May. PMID 17229810
    3. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerol channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables water channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables water channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glycerol transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycerol transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in polyol transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in water transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in water transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Aquaporin-9
    NP_001370535.1
    • Confirmed by transcript evidence
    NP_001379301.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      3025125..3026872
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392739.1 → NP_001379301.1  Aquaporin-9 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6V7QYI0
      Conserved Domains (1) summary
      cd00333
      Location:34 → 273
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

    2. NM_001383537.2 → NP_001370535.1  Aquaporin-9 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21473
      Conserved Domains (1) summary
      cd00333
      Location:23 → 262
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
    Nucleotide Protein
    Heading Accession and Version

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