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    Y43F8B.3 BPTI/Kunitz inhibitor domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180277, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Y43F8B.3
    Official Full Name
    BPTI/Kunitz inhibitor domain-containing protein
    Primary source
    WormBase:WBGene00012814
    Locus tag
    CELE_Y43F8B.3
    See related
    AllianceGenome:WB:WBGene00012814
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Human ortholog(s) of this gene implicated in congenital secretory sodium diarrhea 3. Orthologous to several human genes including WFIKKN1 (WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1); WFIKKN2 (WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2); and SPINT2 (serine peptidase inhibitor, Kunitz type 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See Y43F8B.3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    25
    Sequence:
    Chromosome: V; NC_003283.11 (19503101..19520015)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene SCP domain-containing protein Neighboring gene Fe2OG dioxygenase domain-containing protein Neighboring gene Fe2OG dioxygenase domain-containing protein Neighboring gene ncRNA Neighboring gene GSKIP domain-containing protein Neighboring gene MIF4G domain-containing protein;Prion-like-(Q/N-rich)-domain-bearing protein;Titin;ZM domain-containing protein Neighboring gene ncRNA Neighboring gene DUF19 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    BPTI/Kunitz inhibitor domain-containing protein
    NP_001123046.2
    • Confirmed by transcript evidence
    NP_001123047.2
    • Confirmed by transcript evidence
    NP_001256870.1
    • Partially confirmed by transcript evidence
    NP_001256871.1
    • Confirmed by transcript evidence
    NP_001256872.1
    • Confirmed by transcript evidence
    NP_001256873.1
    • Confirmed by transcript evidence
    NP_001256874.1
    • Confirmed by transcript evidence
    NP_001263941.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      19503101..19520015
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269942.4 → NP_001256871.1  BPTI/Kunitz inhibitor domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256871.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0Z3L4
      Conserved Domains (4) summary
      smart00131
      Location:438 → 490
      KU; BPTI/Kunitz family of serine protease inhibitors
      cd00109
      Location:76 → 126
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:861 → 912
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam14625
      Location:497 → 540
      Lustrin_cystein; Lustrin, cysteine-rich repeated domain

    2. NM_001269943.4 → NP_001256872.1  BPTI/Kunitz inhibitor domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256872.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KMJ6
      Conserved Domains (4) summary
      smart00131
      Location:383 → 435
      KU; BPTI/Kunitz family of serine protease inhibitors
      cd00109
      Location:76 → 126
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:806 → 857
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam14625
      Location:442 → 485
      Lustrin_cystein; Lustrin, cysteine-rich repeated domain

    3. NM_001129574.5 → NP_001123046.2  BPTI/Kunitz inhibitor domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001123046.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XWX5
      Conserved Domains (4) summary
      smart00131
      Location:438 → 490
      KU; BPTI/Kunitz family of serine protease inhibitors
      cd00109
      Location:76 → 126
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:855 → 907
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam14625
      Location:497 → 540
      Lustrin_cystein; Lustrin, cysteine-rich repeated domain

    4. NM_001277012.3 → NP_001263941.1  BPTI/Kunitz inhibitor domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263941.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      K8FDZ2
      Conserved Domains (3) summary
      cd00109
      Location:76 → 126
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:388 → 439
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam14625
      Location:338 → 380
      Lustrin_cystein; Lustrin, cysteine-rich repeated domain

    5. NM_001269944.3 → NP_001256873.1  BPTI/Kunitz inhibitor domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256873.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KMJ9
      Conserved Domains (4) summary
      smart00131
      Location:383 → 435
      KU; BPTI/Kunitz family of serine protease inhibitors
      cd00109
      Location:76 → 126
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:800 → 852
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam14625
      Location:442 → 485
      Lustrin_cystein; Lustrin, cysteine-rich repeated domain

    6. NM_001269941.3 → NP_001256870.1  BPTI/Kunitz inhibitor domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256870.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KMJ7
      Conserved Domains (5) summary
      smart00131
      Location:521 → 573
      KU; BPTI/Kunitz family of serine protease inhibitors
      cd00109
      Location:76 → 126
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:944 → 995
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam14625
      Location:580 → 623
      Lustrin_cystein; Lustrin, cysteine-rich repeated domain
      cl00101
      Location:180 → 231
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

    7. NM_001129575.4 → NP_001123047.2  BPTI/Kunitz inhibitor domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001123047.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A5HW96
      Conserved Domains (4) summary
      smart00131
      Location:438 → 490
      KU; BPTI/Kunitz family of serine protease inhibitors
      cd00109
      Location:76 → 126
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:855 → 907
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam14625
      Location:497 → 540
      Lustrin_cystein; Lustrin, cysteine-rich repeated domain

    8. NM_001269945.3 → NP_001256874.1  BPTI/Kunitz inhibitor domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256874.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0Z3L5
      Conserved Domains (4) summary
      smart00131
      Location:438 → 490
      KU; BPTI/Kunitz family of serine protease inhibitors
      cd00109
      Location:76 → 126
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:861 → 912
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam14625
      Location:497 → 540
      Lustrin_cystein; Lustrin, cysteine-rich repeated domain
    Nucleotide Protein
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