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    act-1 Actin-1 [ Caenorhabditis elegans ]

    Gene ID: 179535, updated on 2-Nov-2024

    Summary

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    Official Symbol
    act-1
    Official Full Name
    Actin-1
    Primary source
    WormBase:WBGene00000063
    Locus tag
    CELE_T04C12.6
    See related
    AllianceGenome:WB:WBGene00000063
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be a structural constituent of cytoskeleton. Involved in cortical actin cytoskeleton organization; embryo development; and mitotic cytokinesis. Located in striated muscle thin filament. Is expressed in Psub4; Z2; Z3; body wall musculature; and gonad. Human ortholog(s) of this gene implicated in Baraitser-Winter syndrome 1; Baraitser-Winter syndrome 2; autosomal dominant nonsyndromic deafness 20; and thrombocytopenia. Orthologous to several human genes including ACTB (actin beta). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See act-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    3
    Sequence:
    Chromosome: V; NC_003283.11 (11081052..11082415)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mammalian cells can trans-splice. But do they? Blumenthal T. Bioessays, 1993 May. PMID 8343144
    2. ACT-5 is an essential Caenorhabditis elegans actin required for intestinal microvilli formation. MacQueen AJ, et al. Mol Biol Cell, 2005 Jul. PMID 15872090, Free PMC Article
    3. Mutations in Caenorhabditis elegans actin, which are equivalent to human cardiomyopathy mutations, cause abnormal actin aggregation in nematode striated muscle. Hayashi Y, et al. F1000Res, 2019. PMID 30984387, Free PMC Article
    4. Imaging of Actin Cytoskeletal Integrity During Aging in C. elegans. Garcia G, et al. Methods Mol Biol, 2022. PMID 34542850
    5. Actin organization and endocytic trafficking are controlled by a network linking NIMA-related kinases to the CDC-42-SID-3/ACK1 pathway. Lažetić V, et al. PLoS Genet, 2018 Apr. PMID 29608564, Free PMC Article

    See all (93) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Repression of CDC-42 or SID-3 suppressed trafficking process that requires actin assembly and disassembly.
      Title: Actin organization and endocytic trafficking are controlled by a network linking NIMA-related kinases to the CDC-42-SID-3/ACK1 pathway.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cortical actin cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitotic cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cytokinesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in striated muscle thin filament IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Actin-1
    NP_505819.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      11081052..11082415
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073418.9 → NP_505819.1  Actin-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505819.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P0DM41, P0DM42, P10983, P10985
      Conserved Domains (1) summary
      PTZ00281
      Location:1 → 376
      PTZ00281; actin; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0DM41.1
    P0DM42.1

    Gene LinkOut

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