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    cpsf-2 putative cleavage and polyadenylation specificity factor subunit 2 [ Caenorhabditis elegans ]

    Gene ID: 179103, updated on 28-Oct-2024

    Summary

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    Official Symbol
    cpsf-2
    Official Full Name
    putative cleavage and polyadenylation specificity factor subunit 2
    Primary source
    WormBase:WBGene00017313
    Locus tag
    CELE_F09G2.4
    See related
    AllianceGenome:WB:WBGene00017313
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in mRNA 3'-end processing by stem-loop binding activity and cleavage. Predicted to be located in nucleus. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Is expressed in anal depressor muscle; body wall musculature; hypodermis; and pharynx. Orthologous to human CPSF2 (cleavage and polyadenylation specific factor 2). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See cpsf-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    9
    Sequence:
    Chromosome: V; NC_003283.11 (7179172..7182858)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ligand-Gated ion Channel Neighboring gene Phosphate transporter Neighboring gene putative phospholipase D F09G2.8 Neighboring gene AT hook Transcription Factor family

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dramatic enhancement of genome editing by CRISPR/Cas9 through improved guide RNA design. Farboud B, et al. Genetics, 2015 Apr. PMID 25695951, Free PMC Article
    2. The C. elegans 3' UTRome v2 resource for studying mRNA cleavage and polyadenylation, 3'-UTR biology, and miRNA targeting. Steber HS, et al. Genome Res, 2019 Dec. PMID 31744903, Free PMC Article
    3. Nuclear pre-mRNA 3'-end processing regulates synapse and axon development in C. elegans. Van Epps H, et al. Development, 2010 Jul. PMID 20530551, Free PMC Article
    4. An evolutionarily conserved role for SRm160 in 3'-end processing that functions independently of exon junction complex formation. McCracken S, et al. J Biol Chem, 2003 Nov 7. PMID 12944400
    5. Genes involved in pre-mRNA 3'-end formation and transcription termination revealed by a lin-15 operon Muv suppressor screen. Cui M, et al. Proc Natl Acad Sci U S A, 2008 Oct 28. PMID 18946043, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA 3'-end processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in mRNA 3'-end processing by stem-loop binding and cleavage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA 3'-end processing by stem-loop binding and cleavage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mRNA cleavage and polyadenylation specificity factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mRNA cleavage and polyadenylation specificity factor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mRNA cleavage and polyadenylation specificity factor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative cleavage and polyadenylation specificity factor subunit 2
    NP_504822.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      7179172..7182858
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072421.5 → NP_504822.1  putative cleavage and polyadenylation specificity factor subunit 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504822.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O17403
      Conserved Domains (5) summary
      smart01027
      Location:242 → 368
      Beta-Casp; Beta-Casp domain
      COG1236
      Location:10 → 376
      YSH1; RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]
      pfam07521
      Location:562 → 601
      RMMBL; RNA-metabolizing metallo-beta-lactamase
      pfam13299
      Location:642 → 840
      CPSF100_C; Cleavage and polyadenylation factor 2 C-terminal
      cd16293
      Location:10 → 203
      CPSF2-like_MBL-fold; cleavage and polyadenylation specificity factor (CPSF) subunit 2 and related proteins; MBL-fold metallo-hydrolase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O17403.1

    Gene LinkOut

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