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    cyn-13 Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase E [ Caenorhabditis elegans ]

    Gene ID: 178487, updated on 28-Oct-2024

    Summary

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    Official Symbol
    cyn-13
    Official Full Name
    Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase E
    Primary source
    WormBase:WBGene00000889
    Locus tag
    CELE_Y116A8C.34
    See related
    AllianceGenome:WB:WBGene00000889
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables nuclease activity. Involved in apoptotic DNA fragmentation. Predicted to be part of catalytic step 2 spliceosome. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Orthologous to human PPIE (peptidylprolyl isomerase E). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See cyn-13 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    3
    Sequence:
    Chromosome: IV; NC_003282.8 (17111081..17116657, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 Neighboring gene Branchpoint-bridging protein Neighboring gene WSN domain-containing protein;protein of unknown function WSN domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RNA-binding protein;Splicing factor U2AF 35 kDa subunit Neighboring gene Intersectin-1;SH3 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. U2AF35 is encoded by an essential gene clustered in an operon with RRM/cyclophilin in Caenorhabditis elegans. Zorio DA, et al. RNA, 1999 Apr. PMID 10199565, Free PMC Article
    2. Splicing factor SF1 from Drosophila and Caenorhabditis: presence of an N-terminal RS domain and requirement for viability. Mazroui R, et al. RNA, 1999 Dec. PMID 10606272, Free PMC Article
    3. DNase II: genes, enzymes and function. Evans CJ, et al. Gene, 2003 Dec 11. PMID 14644493
    4. Functional genomic analysis of apoptotic DNA degradation in C. elegans. Parrish JZ, et al. Mol Cell, 2003 Apr. PMID 12718884
    5. Identification and comparative analysis of the peptidyl-prolyl cis/trans isomerase repertoires of H. sapiens, D. melanogaster, C. elegans, S. cerevisiae and Sz. pombe. Pemberton TJ, et al. Comp Funct Genomics, 2005. PMID 18629211, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclosporin A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic DNA fragmentation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in apoptotic DNA fragmentation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein peptidyl-prolyl isomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase E
    NP_001255925.1
    • Confirmed by transcript evidence
    NP_001255926.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      17111081..17116657 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268996.2 → NP_001255925.1  Peptidyl-prolyl cis-trans isomerase E [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255925.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U2S6
      Conserved Domains (3) summary
      COG0724
      Location:10 → 115
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd01926
      Location:139 → 297
      cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
      cd12347
      Location:13 → 85
      RRM_PPIE; RNA recognition motif in cyclophilin-33 (Cyp33) and similar proteins

    2. NM_001268997.3 → NP_001255926.1  Peptidyl-prolyl cis-trans isomerase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255926.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3NQB1
      Conserved Domains (1) summary
      cl00197
      Location:2 → 69
      cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...
    Nucleotide Protein
    Heading Accession and Version

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