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    cpsf-3 Cleavage and polyadenylation specificity factor subunit 3 [ Caenorhabditis elegans ]

    Gene ID: 178285, updated on 28-Oct-2024

    Summary

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    Official Symbol
    cpsf-3
    Official Full Name
    Cleavage and polyadenylation specificity factor subunit 3
    Primary source
    WormBase:WBGene00013460
    Locus tag
    CELE_Y67H2A.1
    See related
    AllianceGenome:WB:WBGene00013460
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 5'-3' RNA exonuclease activity; RNA binding activity; and RNA endonuclease activity. Predicted to be involved in mRNA 3'-end processing by stem-loop binding activity and cleavage. Predicted to be located in nucleus. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Is expressed in excretory cell; intestine; spermathecal-uterine junction; and tail. Orthologous to human CPSF3 (cleavage and polyadenylation specific factor 3). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See cpsf-3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    10
    Sequence:
    Chromosome: IV; NC_003282.8 (13273846..13282878, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Transmembrane protein Neighboring gene Transmembrane protein Neighboring gene Synaptojanin Neighboring gene C2H2-type domain-containing protein Neighboring gene Kelch domain-containing protein 10

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The C. elegans 3' UTRome v2 resource for studying mRNA cleavage and polyadenylation, 3'-UTR biology, and miRNA targeting. Steber HS, et al. Genome Res, 2019 Dec. PMID 31744903, Free PMC Article
    2. An evolutionarily conserved role for SRm160 in 3'-end processing that functions independently of exon junction complex formation. McCracken S, et al. J Biol Chem, 2003 Nov 7. PMID 12944400
    3. ABCE1 is a highly conserved RNA silencing suppressor. Kärblane K, et al. PLoS One, 2015. PMID 25659154, Free PMC Article
    4. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article
    5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 5'-3' RNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA 3'-end processing by stem-loop binding and cleavage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mRNA cleavage and polyadenylation specificity factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cleavage and polyadenylation specificity factor subunit 3
    NP_502553.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      13273846..13282878 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_070152.6 → NP_502553.2  Cleavage and polyadenylation specificity factor subunit 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502553.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95PY8
      Conserved Domains (5) summary
      smart01027
      Location:247 → 368
      Beta-Casp; Beta-Casp domain
      smart01098
      Location:477 → 694
      CPSF73-100_C; This is the C-terminal conserved region of the pre-mRNA 3'-end-processing of the polyadenylation factor CPSF-73/CPSF-100 proteins
      COG1236
      Location:13 → 456
      YSH1; RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]
      pfam07521
      Location:381 → 421
      RMMBL; RNA-metabolizing metallo-beta-lactamase
      cd16292
      Location:11 → 206
      CPSF3-like_MBL-fold; cleavage and polyadenylation specificity factor (CPSF) subunit 3 and related proteins; MBL-fold metallo-hydrolase domain
    Nucleotide Protein
    Heading Accession and Version

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