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    pfd-1 putative prefoldin subunit 1 [ Caenorhabditis elegans ]

    Gene ID: 178021, updated on 2-Nov-2024

    Summary

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    Official Symbol
    pfd-1
    Official Full Name
    putative prefoldin subunit 1
    Primary source
    WormBase:WBGene00007443
    Locus tag
    CELE_C08F8.1
    See related
    AllianceGenome:WB:WBGene00007443
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein folding chaperone and unfolded protein binding activity. Involved in gonad development. Located in cytoplasm. Is expressed in body wall musculature; excretory cell; intestine; pharynx; and vulval muscle. Orthologous to human PFDN1 (prefoldin subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See pfd-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    3
    Sequence:
    Chromosome: IV; NC_003282.8 (11150113..11150930)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Phosphate carrier protein, mitochondrial Neighboring gene ncRNA Neighboring gene ATP-dependent RNA helicase SUV3 homolog, mitochondrial Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Efficient chaperone-mediated tubulin biogenesis is essential for cell division and cell migration in C. elegans. Lundin VF, et al. Dev Biol, 2008 Jan 1. PMID 18062952
    2. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article
    3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein folding chaperone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in gonad development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of prefoldin complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative prefoldin subunit 1
    NP_001255540.1
    • Confirmed by transcript evidence
    NP_001255541.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      11150113..11150930
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268611.4 → NP_001255540.1  putative prefoldin subunit 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255540.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E9P871, Q17827
      Conserved Domains (1) summary
      pfam01920
      Location:11 → 114
      Prefoldin_2; Prefoldin subunit

    2. NM_001268612.4 → NP_001255541.1  putative prefoldin subunit 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255541.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q17827
      Conserved Domains (1) summary
      pfam01920
      Location:1 → 77
      Prefoldin_2; Prefoldin subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q17827.1

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