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    icln-1 Methylosome subunit pICln [ Caenorhabditis elegans ]

    Gene ID: 177730, updated on 2-Nov-2024

    Summary

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    Official Symbol
    icln-1
    Official Full Name
    Methylosome subunit pICln
    Primary source
    WormBase:WBGene00002046
    Locus tag
    CELE_C01F6.8
    See related
    AllianceGenome:WB:WBGene00002046
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in mRNA cis splicing, via spliceosome and spliceosomal snRNP assembly. Predicted to be located in cytoplasm; nucleus; and plasma membrane. Predicted to be part of pICln-Sm protein complex and spliceosomal complex. Predicted to be active in cytosol. Orthologous to human CLNS1A (chloride nucleotide-sensitive channel 1A). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See icln-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (9094552..9095653, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Transmembrane protein Neighboring gene Octanoyl-[acyl-carrier-protein]:protein N-octanoyltransferase LIPT2, mitochondrial Neighboring gene Large ribosomal subunit protein mL42 Neighboring gene 4F5 domain-containing protein;Small EDRK-rich factor-like N-terminal domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ICln ion channel splice variants in Caenorhabditis elegans: voltage dependence and interaction with an operon partner protein. Fürst J, et al. J Biol Chem, 2002 Feb 8. PMID 11706026
    2. Ethanol-response genes and their regulation analyzed by a microarray and comparative genomic approach in the nematode Caenorhabditis elegans. Kwon JY, et al. Genomics, 2004 Apr. PMID 15028283
    3. A new gene-finding tool: using the Caenorhabditis elegans operons for identifying functional partner proteins in human cells. Eichmüller S, et al. J Biol Chem, 2004 Feb 20. PMID 14615488
    4. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in cell volume homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chloride transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA cis splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spliceosomal snRNP assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spliceosomal snRNP assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of methylosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of pICln-Sm protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of pICln-Sm protein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Methylosome subunit pICln
    NP_001021288.1
    • Partially confirmed by transcript evidence
    NP_001379098.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      9094552..9095653 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392361.1 → NP_001379098.1  Methylosome subunit pICln [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFZ5
      Conserved Domains (1) summary
      pfam03517
      Location:32 → 140
      Voldacs; Regulator of volume decrease after cellular swelling

    2. NM_001026117.4 → NP_001021288.1  Methylosome subunit pICln [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021288.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EG22
      Conserved Domains (1) summary
      pfam03517
      Location:32 → 160
      Voldacs; Regulator of volume decrease after cellular swelling
    Nucleotide Protein
    Heading Accession and Version

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