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    lin-49 Protein lin-49 [ Caenorhabditis elegans ]

    Gene ID: 177666, updated on 2-Nov-2024

    Summary

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    Official Symbol
    lin-49
    Official Full Name
    Protein lin-49
    Primary source
    WormBase:WBGene00003034
    Locus tag
    CELE_F42A9.2
    See related
    AllianceGenome:WB:WBGene00003034
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable histone binding activity and nucleosome binding activity. Involved in cell fate specification; maintenance of left/right asymmetry; and positive regulation of gene expression. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in bipolar disorder and schizophrenia. Orthologous to several human genes including BRPF1 (bromodomain and PHD finger containing 1) and BRPF3 (bromodomain and PHD finger containing 3). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See lin-49 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    10
    Sequence:
    Chromosome: IV; NC_003282.8 (8620683..8626162)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Transmembrane protein Neighboring gene CBFD_NFYB_HMF domain-containing protein;Transposase Neighboring gene Secreted protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Maintenance of neuronal laterality in Caenorhabditis elegans through MYST histone acetyltransferase complex components LSY-12, LSY-13 and LIN-49. O'Meara MM, et al. Genetics, 2010 Dec. PMID 20923973, Free PMC Article
    2. A novel C. elegans zinc finger transcription factor, lsy-2, required for the cell type-specific expression of the lsy-6 microRNA. Johnston RJ Jr, et al. Development, 2005 Dec. PMID 16291785
    3. Taking sides in the nervous system with miRNA. Sengupta P. Nat Neurosci, 2004 Feb. PMID 14747830
    4. Characterization of seven genes affecting Caenorhabditis elegans hindgut development. Chamberlin HM, et al. Genetics, 1999 Oct. PMID 10511553, Free PMC Article
    5. MicroRNAs act sequentially and asymmetrically to control chemosensory laterality in the nematode. Chang S, et al. Nature, 2004 Aug 12. PMID 15306811

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maintenance of left/right asymmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Protein lin-49
    NP_501475.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      8620683..8626162
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069074.7 → NP_501475.1  Protein lin-49 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501475.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20318
      Conserved Domains (5) summary
      smart00297
      Location:508 → 610
      BROMO; bromo domain
      pfam05642
      Location:642 → 1029
      Sporozoite_P67; Sporozoite P67 surface antigen
      cd15492
      Location:197 → 242
      PHD_BRPF_JADE_like; PHD finger found in BRPF proteins, Jade proteins, protein AF-10, AF-17, and similar proteins
      pfam10513
      Location:61 → 174
      EPL1; Enhancer of polycomb-like
      pfam13832
      Location:251 → 365
      zf-HC5HC2H_2; PHD-zinc-finger like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q20318.1

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