cerk-1 Ceramide kinase 1 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: cerk-1
Gene description: Ceramide kinase 1
Locus tag: CELE_T10B11.2
See related: AllianceGenome:WB:WBGene00020398
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ceramide kinase activity. Predicted to be involved in ceramide metabolic process and phosphorylation. Is expressed in hypodermis; intestine; nervous system; and reproductive system. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 26. Orthologous to several human genes including CERK (ceramide kinase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See cerk-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 11

Sequence:: Chromosome: I; NC_003279.8 (6931138..6936928)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T10B11.2 (e-PCR)
- UniSTS:314953

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ceramide kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ceramide kinase activity	IEA Inferred from Electronic Annotation more info
enables dihydroceramide kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ceramide metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in sphingolipid metabolic process	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Ceramide kinase 1

NP_491977.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

6931138..6936928

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059576.7 → NP_491977.1 Ceramide kinase 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491977.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9TZI1

Conserved Domains (2) summary

PLN02204
Location:149 → 505

PLN02204; diacylglycerol kinase

COG1597
Location:165 → 525

LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]