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    pgs-1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase [ Caenorhabditis elegans ]

    Gene ID: 171594, updated on 19-Jun-2024

    Summary

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    Gene symbol
    pgs-1
    Gene description
    CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
    Locus tag
    CELE_Y48G1C.4
    See related
    AllianceGenome:WB:WBGene00021677
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity. Involved in regulation of cell population proliferation and regulation of mitochondrial membrane potential. Predicted to be active in mitochondrion. Orthologous to human PGS1 (phosphatidylglycerophosphate synthase 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See pgs-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (49921..54426)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene transcellular chaperone signaling (x)cross tissue Neighboring gene Anaphase-promoting complex subunit 10 Neighboring gene Tyrosine-protein phosphatase domain-containing protein Neighboring gene Serine-threonine/tyrosine-protein kinase catalytic domain-containing protein;Tyrosine-protein kinase csk-1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inactivation of cardiolipin synthase triggers changes in mitochondrial morphology. Matsumura A, et al. FEBS Lett, 2018 Jan. PMID 29251771
    2. Deficiency of cardiolipin synthase causes abnormal mitochondrial function and morphology in germ cells of Caenorhabditis elegans. Sakamoto T, et al. J Biol Chem, 2012 Feb 10. PMID 22174409, Free PMC Article
    3. Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans. Gottschalk A, et al. EMBO J, 2005 Jul 20. PMID 15990870, Free PMC Article
    4. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cardiolipin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cardiolipin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylglycerol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylglycerol biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitochondrial membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
    NP_001364825.1
    • Confirmed by transcript evidence
    NP_490666.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      49921..54426
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058265.6 → NP_490666.2  CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490666.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BL79
      Conserved Domains (2) summary
      cd09135
      Location:17 → 182
      PLDc_PGS1_euk_1; Catalytic domain, repeat 1, of eukaryotic PhosphatidylGlycerophosphate Synthases
      cd09137
      Location:242 → 417
      PLDc_PGS1_euk_2; Catalytic domain, repeat 2, of eukaryotic phosphatidylglycerophosphate synthases

    2. NM_001377579.2 → NP_001364825.1  CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CIR3
      Conserved Domains (2) summary
      cd09137
      Location:109 → 284
      PLDc_PGS1_euk_2; Catalytic domain, repeat 2, of eukaryotic phosphatidylglycerophosphate synthases
      cl15239
      Location:1 → 49
      PLDc_SF; Catalytic domain of phospholipase D superfamily proteins
    Nucleotide Protein
    Heading Accession and Version

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