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    Pabpc1 poly(A) binding protein, cytoplasmic 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171350, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Pabpc1provided by RGD
    Official Full Name
    poly(A) binding protein, cytoplasmic 1provided by RGD
    Primary source
    RGD:619838
    See related
    EnsemblRapid:ENSRNOG00000008639 AllianceGenome:RGD:619838
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pabp; Pabp1; PABP 1
    Summary
    Enables mRNA binding activity. Predicted to be involved in gene silencing by RNA; positive regulation of viral genome replication; and regulation of mRNA catabolic process. Located in dendrite. Part of messenger ribonucleoprotein complex. Orthologous to several human genes including PABPC1 (poly(A) binding protein cytoplasmic 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 2043.7), Testes (RPKM 698.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pabpc1 in Genome Data Viewer
    Location:
    7q22
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (69662513..69674806, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (67777438..67789731, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (75409581..75421874, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479895 Neighboring gene ankyrin repeat domain 46 Neighboring gene sorting nexin 31 Neighboring gene uncharacterized LOC134479712 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Long noncoding RNA-dependent regulation of vascular smooth muscle cell proliferation and migration in hypertension. Tan J, et al. Int J Biochem Cell Biol, 2020 Jan. PMID 31743794
    2. Vasopressin mRNA localization in nerve cells: characterization of cis-acting elements and trans-acting factors. Mohr E, et al. Proc Natl Acad Sci U S A, 2001 Jun 19. PMID 11416190, Free PMC Article
    3. Insulin receptor substrate-1 (IRS-1) forms a ribonucleoprotein complex associated with polysomes. Ozoe A, et al. FEBS Lett, 2013 Aug 2. PMID 23770097
    4. Molecular composition of staufen2-containing ribonucleoproteins in embryonic rat brain. Maher-Laporte M, et al. PLoS One, 2010 Jun 28. PMID 20596529, Free PMC Article
    5. Comparative peptide binding studies of the PABC domains from the ubiquitin-protein isopeptide ligase HYD and poly(A)-binding protein. Implications for HYD function. Lim NS, et al. J Biol Chem, 2006 May 19. PMID 16554297

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Long noncoding RNA-dependent regulation of vascular smooth muscle cell proliferation and migration in hypertension.
      Title: Long noncoding RNA-dependent regulation of vascular smooth muscle cell proliferation and migration in hypertension.
    2. PABC domains from the ubiquitin-protein isopeptide ligase HYD and poly(A)-binding protein
      Title: Comparative peptide binding studies of the PABC domains from the ubiquitin-protein isopeptide ligase HYD and poly(A)-binding protein. Implications for HYD function.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC91496

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables poly(A) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(A) binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables poly(A) binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables poly(U) RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(U) RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in CRD-mediated mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cytoplasmic translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulatory ncRNA-mediated gene silencing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulatory ncRNA-mediated gene silencing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell leading edge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell leading edge ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic stress granule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mCRD-mediated mRNA stability complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    polyadenylate-binding protein 1
    Names
    PABP-1
    poly(A)-binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134353.3 → NP_599180.1  polyadenylate-binding protein 1

      See identical proteins and their annotated locations for NP_599180.1

      Status: PROVISIONAL

      Source sequence(s)
      AJ298278
      UniProtKB/Swiss-Prot
      Q9EPH8
      UniProtKB/TrEMBL
      A0A0G2JZS2, A6HR30
      Related
      ENSRNOP00000012775.5, ENSRNOT00000012775.9
      Conserved Domains (6) summary
      TIGR01628
      Location:11 → 615
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12378
      Location:12 → 91
      RRM1_I_PABPs; RNA recognition motif 1 in type I polyadenylate-binding proteins
      cd12379
      Location:97 → 172
      RRM2_I_PABPs; RNA recognition motif 2 found in type I polyadenylate-binding proteins
      cd12380
      Location:190 → 269
      RRM3_I_PABPs; RNA recognition motif 3 found in type I polyadenylate-binding proteins
      cd12381
      Location:293 → 370
      RRM4_I_PABPs; RNA recognition motif 4 in type I polyadenylate-binding proteins
      pfam00658
      Location:547 → 614
      PABP; Poly-adenylate binding protein, unique domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      69662513..69674806 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EPH8.1 GenPept UniProtKB/Swiss-Prot:Q9EPH8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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