Serpina10 serpin family A member 10 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Serpina10provided by RGD
Full Name: serpin family A member 10provided by RGD
Primary source: RGD:621220
See related: EnsemblRapid:ENSRNOG00000050761 AllianceGenome:RGD:621220
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rasp1
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Involved in liver regeneration. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in thrombophilia. Orthologous to human SERPINA10 (serpin family A member 10). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Restricted expression toward (RPKM 1350.4) See more
Orthologs: human mouse all
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Genomic context

Location:: 6q32

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (128520894..128529332, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (122756106..122764544, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (127500014..127508470, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in blood coagulation	IEA Inferred from Electronic Annotation more info
involved_in liver regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info
NOT involved_in regulation of acrosome reaction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein Z-dependent protease inhibitor

Names: PZ-dependent protease inhibitor; PZI; RASP-1; plasma protein associated with liver regeneration; protein Z-dependent protease inhibitor-like; regeneration-associated serpin 1; serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10; serpin A10; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10; serpin peptidase inhibitor, clade A, member 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133617.2 → NP_598301.2 protein Z-dependent protease inhibitor precursor

See identical proteins and their annotated locations for NP_598301.2

Status: PROVISIONAL

Source sequence(s)

BC088113

UniProtKB/Swiss-Prot

Q5M8C2, Q62975

UniProtKB/TrEMBL

A6JEN7, A6JEN8

Related

ENSRNOP00000064104.1, ENSRNOT00000073709.3

Conserved Domains (1) summary

cl00137
Location:66 → 430

SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...