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    Eif4g2 eukaryotic translation initiation factor 4, gamma 2 [ Mus musculus (house mouse) ]

    Gene ID: 13690, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Eif4g2provided by MGI
    Official Full Name
    eukaryotic translation initiation factor 4, gamma 2provided by MGI
    Primary source
    MGI:MGI:109207
    See related
    Ensembl:ENSMUSG00000005610 AllianceGenome:MGI:109207
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p97; Nat1; DAP-5; Natm1; E130105L11Rik
    Summary
    Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G, that contains the binding sites for eIF4A and eIF3; eIF4G in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. Transgene expression of the apolipoprotein B mRNA-editing enzyme (APOBEC-1) causes extensive editing of this mRNA, which could contribute to the potent oncogenesis induced by overexpression of APOBEC-1. In vitro and in vivo studies in human indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. This also appears to be true for mouse. Two alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 106.9), CNS E14 (RPKM 96.1) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Eif4g2 in Genome Data Viewer
    Location:
    7 E3; 7 58.0 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (110667192..110682237, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (111067985..111083030, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene inositol 1,4,5-triphosphate receptor associated 1 Neighboring gene STARR-seq mESC enhancer starr_19834 Neighboring gene predicted gene 16336 Neighboring gene STARR-seq mESC enhancer starr_19835 Neighboring gene STARR-seq mESC enhancer starr_19836 Neighboring gene STARR-positive B cell enhancer ABC_E9701 Neighboring gene CTR9 homolog, Paf1/RNA polymerase II complex component Neighboring gene STARR-seq mESC enhancer starr_19838 Neighboring gene predicted gene, 23262 Neighboring gene STARR-positive B cell enhancer ABC_E3743 Neighboring gene zinc finger, BED type containing 5, pseudogene Neighboring gene predicted gene, 33098

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Essential role of NAT1/p97/DAP5 in embryonic differentiation and the retinoic acid pathway. Yamanaka S, et al. EMBO J, 2000 Oct 16. PMID 11032820, Free PMC Article
    2. Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding. Hacisuleyman E, et al. Nat Neurosci, 2024 May. PMID 38589584, Free PMC Article
    3. Thyroid hormone increases bulk histones expression by enhancing translational efficiency. Zambrano A, et al. Mol Endocrinol, 2015 Jan. PMID 25422881, Free PMC Article
    4. Eukaryotic initiation factor 4 gamma 2 contributes to neuropathic pain through down-regulation of Kv1.2 and the mu opioid receptor in mouse primary sensory neurones. Zhang Z, et al. Br J Anaesth, 2021 Mar. PMID 33303185, Free PMC Article
    5. A new translational regulator with homology to eukaryotic translation initiation factor 4G. Imataka H, et al. EMBO J, 1997 Feb 17. PMID 9049310, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding.
      Title: Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding.
    2. miR-379-5P INHIBITION ENHANCES INTESTINAL EPITHELIAL PROLIFERATION AND BARRIER FUNCTION RECOVERY AFTER ISCHEMIA/REPERFUSION BY TARGETING EIF4G2.
      Title: miR-379-5P INHIBITION ENHANCES INTESTINAL EPITHELIAL PROLIFERATION AND BARRIER FUNCTION RECOVERY AFTER ISCHEMIA/REPERFUSION BY TARGETING EIF4G2.
    3. Eukaryotic initiation factor 4 gamma 2 contributes to neuropathic pain through down-regulation of Kv1.2 and the mu opioid receptor in mouse primary sensory neurones.
      Title: Eukaryotic initiation factor 4 gamma 2 contributes to neuropathic pain through down-regulation of Kv1.2 and the mu opioid receptor in mouse primary sensory neurones.
    4. Findings suggest a new translational regulatory mechanism for DSCR1.4 expressions and a novel function of DAP5 as a positive regulator of DSCR1.4 mRNA translation induced in soma and axon of hippocampal neurons.
      Title: DAP5 increases axonal outgrowth of hippocampal neurons by enhancing the cap-independent translation of DSCR1.4 mRNA.
    5. analysis of the tandem MA-3 region of Pdcd4 protein and characterization of its interactions with eIF4A and eIF4G
      Title: Structure of the tandem MA-3 region of Pdcd4 protein and characterization of its interactions with eIF4A and eIF4G: molecular mechanisms of a tumor suppressor.
    6. in vitro and in vivo studies in human show that translation starts at a non-AUG (GUG) codon. Suggest the same in mouse based on sequence conservation.
      Title: A new translational regulator with homology to eukaryotic translation initiation factor 4G.
    7. translation starts at a non-AUG translation initiation codon (GUG).
      Title: cDNA cloning, expression analysis, and chromosomal localization of a gene with high homology to wheat eIF-(iso)4F and mammalian eIF-4G.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation factor activity, RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation factor activity, RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables translation initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation initiation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in macromolecule biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of translational initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of eukaryotic translation initiation factor 4F complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 4F complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of eukaryotic translation initiation factor 4F complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in postsynaptic density EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 4 gamma 2
    Names
    eIF-4-gamma 2
    eIF-4G 2
    eIF4G 2
    novel APOBEC-1 target 1
    translation repressor Nat1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040131.2 → NP_001035221.1  eukaryotic translation initiation factor 4 gamma 2 isoform 2

      See identical proteins and their annotated locations for NP_001035221.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC150312, AC159206, AI874618, BC043034
      Consensus CDS
      CCDS40087.1
      UniProtKB/TrEMBL
      F7CBP1
      Related
      ENSMUSP00000125375.2, ENSMUST00000161051.8
      Conserved Domains (4) summary
      cd11559
      Location:701 → 837
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      smart00544
      Location:505 → 618
      MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
      pfam02854
      Location:78 → 308
      MIF4G; MIF4G domain
      pfam11235
      Location:412 → 509
      Med25_SD1; Mediator complex subunit 25 synapsin 1

    2. NM_013507.3 → NP_038535.2  eukaryotic translation initiation factor 4 gamma 2 isoform 1

      See identical proteins and their annotated locations for NP_038535.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
      Source sequence(s)
      AC150312, AI874618, BC043034
      Consensus CDS
      CCDS40088.1
      UniProtKB/Swiss-Prot
      P97867, Q0VGZ3, Q3UNC1, Q5XKD8, Q62448, Q6P1Z0, Q921U3
      UniProtKB/TrEMBL
      A0JNY7, G3XA17
      Related
      ENSMUSP00000124551.2, ENSMUST00000162415.9
      Conserved Domains (3) summary
      cd11559
      Location:739 → 875
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      smart00544
      Location:543 → 656
      MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
      pfam02854
      Location:78 → 308
      MIF4G; MIF4G domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      110667192..110682237 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62448.2 GenPept UniProtKB/Swiss-Prot:Q62448

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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