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    Ctse cathepsin E [ Mus musculus (house mouse) ]

    Gene ID: 13034, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Ctseprovided by MGI
    Official Full Name
    cathepsin Eprovided by MGI
    Primary source
    MGI:MGI:107361
    See related
    Ensembl:ENSMUSG00000004552 AllianceGenome:MGI:107361
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CE; CatE; A430072O03Rik; C920004C08Rik
    Summary
    This gene encodes a member of the peptidase A1 family of aspartate proteases and preproprotein that is proteolytically processed to generate a mature protein product. The encoded protein may be involved in antigen processing and the maturation of secretory proteins. Elevated expression of this gene has been observed in neurodegeneration. Homozygous knockout mice for this gene exhibit lysosomal storage disorder, impaired autophagy, mitochondrial abnormalities, dermatitis, and reduced weight gain in an obesity model. [provided by RefSeq, Aug 2015]
    Expression
    Biased expression in stomach adult (RPKM 438.1), bladder adult (RPKM 70.7) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ctse in Genome Data Viewer
    Location:
    1 E4; 1 57.14 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (131566052..131603245)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (131638314..131675507)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene arginine vasopressin receptor 1B Neighboring gene STARR-positive B cell enhancer ABC_E11085 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:133534791-133534974 Neighboring gene adaptor-related protein complex AP-1, sigma 3 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:133554451-133554634 Neighboring gene STARR-seq mESC enhancer starr_02223 Neighboring gene RAB7B, member RAS oncogene family Neighboring gene predicted gene, 30104

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The role of cathepsin E in terminal differentiation of keratinocytes. Kawakubo T, et al. Biol Chem, 2011 Apr. PMID 21521076
    2. Downregulated Cathepsin E expression in bone marrow-derived macrophages from the pre-clinical familial amyloid polyneuropathy model. Moreira J, et al. Amyloid, 2019. PMID 31343320
    3. Cathepsin E in neutrophils contributes to the generation of neuropathic pain in experimental autoimmune encephalomyelitis. Harada Y, et al. Pain, 2019 Sep. PMID 31095099, Free PMC Article
    4. Impaired chemotaxis and cell adhesion due to decrease in several cell-surface receptors in cathepsin E-deficient macrophages. Tsukuba T, et al. J Biochem, 2009 May. PMID 19174547
    5. Decreased expression of MHC class II and cathepsin E in dendritic cells might contribute to impaired induction of antigen-specific T cell response in NC/Nga mice. Sakai T, et al. J Med Invest, 2012. PMID 22449997

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Regulation of Cathepsin E gene expression by the transcription factor Kaiso in MRL/lpr mice derived CD4+ T cells.
      Title: Regulation of Cathepsin E gene expression by the transcription factor Kaiso in MRL/lpr mice derived CD4+ T cells.
    2. Cathepsin-E deficient animals were highly resistant to (MOG35-55) induced mechanical allodynia.
      Title: Cathepsin E in neutrophils contributes to the generation of neuropathic pain in experimental autoimmune encephalomyelitis.
    3. Infact, decreased CtsE expression levels in BMDM of V30Mmice and their apparent impairment observed to LPSresponse could explain the mechanism for lower immunecell chemotaxis and impaired macrophage function observedin familial amyloid polyneuropathy.
      Title: Downregulated Cathepsin E expression in bone marrow-derived macrophages from the pre-clinical familial amyloid polyneuropathy model.
    4. Cathepsin E, mitochondrial fission, and caspase activation/apoptosis are linked in the pathogenesis of pulmonary emphysema.
      Title: Cathepsin E promotes pulmonary emphysema via mitochondrial fission.
    5. These results indicate that cathepsin E deficiency causes autophagy impairment concomitantly with increased aberrant mitochondria as well as increased oxidative stress.
      Title: Cathepsin E deficiency impairs autophagic proteolysis in macrophages.
    6. impaired adipose tissue development in high fat diet-induced CatE(-/-) mice was probably due to reduced infiltration of macrophages and may lead to hepatomegaly accompanied by hepatic steatosis and hypercholesterolemia
      Title: Defective adipose tissue development associated with hepatomegaly in cathepsin E-deficient mice fed a high-fat diet.
    7. L1 stimulation triggers sumoylation and cleavage of L1, thus generating the L1-70 fragment which is cleaved by cathepsin E
      Title: Cathepsin E generates a sumoylated intracellular fragment of the cell adhesion molecule L1 to promote neuronal and Schwann cell migration as well as myelination.
    8. Intradermal cathepsin E has pruritogenic activity, which is at least partly mediated by the production of endothelin-1.
      Title: Cathepsin E induces itch-related response through the production of endothelin-1 in mice.
    9. Low expression levels of MHC class II and cathepsin E might contribute to the defect in induction of Ag-specific T cells in NC mice.
      Title: Decreased expression of MHC class II and cathepsin E in dendritic cells might contribute to impaired induction of antigen-specific T cell response in NC/Nga mice.
    10. Results suggest that Sp1 binding plays a particularly important role in the regulation of cathepsin E gene expression.
      Title: Role of the transcription factor Sp1 in regulating the expression of the murine cathepsin E gene.
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aspartic-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aspartic-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autoprocessing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein autoprocessing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cathepsin E
    NP_031825.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007799.3 → NP_031825.2  cathepsin E preproprotein

      See identical proteins and their annotated locations for NP_031825.2

      Status: REVIEWED

      Source sequence(s)
      AC120217, AC138277, AK145875
      Consensus CDS
      CCDS15271.1
      UniProtKB/Swiss-Prot
      O35647, P70269, Q3UKT5, Q4FK00
      UniProtKB/TrEMBL
      D3Z6T3
      Related
      ENSMUSP00000073072.7, ENSMUST00000073350.13
      Conserved Domains (3) summary
      pfam00026
      Location:78 → 395
      Asp; Eukaryotic aspartyl protease
      pfam07966
      Location:22 → 50
      A1_Propeptide; A1 Propeptide
      cl11403
      Location:79 → 394
      pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      131566052..131603245
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70269.2 GenPept UniProtKB/Swiss-Prot:P70269

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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